지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 141 - 147 (7page)
이용수
초록· 키워드
오류제보하기
Vascular endothelial growth factor (VEGF) is an important signaling protein involved in angiogenesis, which is the formation of new blood vessels from pre-existing vessels. Consequently, blocking of the vascular endothelial growth factor receptor (VEGFR-2) by small molecule inhibitors leads to the inhibition of cancer induced angiogenesis. In this study, we performed a two dimensional quantitative structure activity relationship (2D-QSAR) study of 38 N-Phenyl-N'-{4-(4-quinolyloxy) phenyl} urea derivatives as VEGFR-2 inhibitors based on hologram quantitative structure-activity (HQSAR). The model developed showed reasonable $q^2=0.521$ and $r^2=0.932$ values indicating good predictive ability and reliability. The atomic contribution map analysis of most active compound (compound 7) indicates that hydrogen and oxygen atoms in the side chain of ring A and oxygen atom in side chain of ring C contributes positively to the activity of the compounds. The HQSAR model developed and the atomic contribution map can serve as a guideline in designing new compounds for VEGFR-2 inhibition.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Soluble Expression and Purification of the Catalytic Domain of Human Vascular Endothelial Growth Factor Receptor 2 in Escherichia coli
Journal of Microbiology and Biotechnology
2015 .01
-
Identification of VEGFR2 kinase inhibitors using virtual screening based on machine learning model and molecular dynamics simulations
한국분석과학회 학술대회
2022 .11
-
Oleanolic Acids Inhibit Vascular Endothelial Growth Factor Receptor 2 Signaling in Endothelial Cells: Implication for Anti-Angiogenic Therapy
Molecules and Cells
2018 .08
-
HQSAR Study on Imidazo[1,2-b]pyridazine Derivatives as p38 MAP Kinase Antagonists
조선자연과학논문집
2018 .01
-
HQSAR Study on Substituted 1H-Pyrazolo[3,4-b]pyridines Derivatives as FGFR Kinase Antagonists
조선자연과학논문집
2017 .01
-
(E)-2-Methoxy-4-(3-(4-Methoxyphenyl) Prop-1-en-1-yl) Phenol Suppresses Breast Cancer Progression by Dual-Regulating VEGFR2 and PPARγ
Journal of Microbiology and Biotechnology
2024 .02
-
14-3-3 proteins contribute to leaf and root development via Brassinosteroid Insensitive 1 in Arabidopsis thaliana
Genes & Genomics
2020 .01
-
Synthesis of (Z)-3-((1H-imidazol-5-yl)methylene)indolin-2-one Derivatives as Pim Kinase Inhibitors
Quantitative Bio-Science
2018 .05
-
Ligand Based HQSAR Analysis of CRTh2 Antagonists
조선자연과학논문집
2015 .01
-
The Histone Methyltransferase Inhibitor BIX01294 Inhibits HIF-1α Stability and Angiogenesis
Molecules and Cells
2015 .06
-
1,3,4-Oxadiazole-2(3H)-thione as a New Scaffold for Pim Kinase Inhibitors
Quantitative Bio-Science
2018 .11
-
3D-QSAR Study on Imidazopyridazines Derivatives as Potent Pim-1 Kinase Inhibitors using Region-Focused CoMFA
조선자연과학논문집
2017 .01
-
Hologram Based QSAR Analysis of Xanthine Oxidase Inhibitors
조선자연과학논문집
2017 .01
-
Discovery of PIM Kinase Inhibitor: 1,3,4-oxadiazole-2(3H)-thione Analogs
Quantitative Bio-Science
2020 .05
-
스핑고신 키나아제 저해제의 합성과 췌장암 세포에서의 항암활성 연구
대한화학회지
2022 .04
-
Impact of VEGFA promoter polymorphisms on esophageal cancer risk in North-West Indians: a case-control study
Genes & Genomics
2022 .08
-
Adenylate Kinase Modulates Pneumococcal Capsule via Autophosphotyrosine Kinase
한국미생물학회 학술대회논문집
2015 .04
-
1,6-Disubstituted-1H-benzo[d]imidazol-2(3H)-one Derivatives as PIM Kinase Inhibitors
Quantitative Bio-Science
2022 .05
-
Hologram Based QSAR Analysis of CXCR-2 Inhibitors
조선자연과학논문집
2017 .01
-
3D QSAR Studies of Mps1 (TTK) Kinase Inhibitors Based on CoMFA
조선자연과학논문집
2016 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0