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자료유형
학술저널
저자정보
Hwang, Hye-Jeong (Acupuncture & Meridian Science Research Center, Kyung-Hee University) Kim, Seung-Tae (Acupuncture & Meridian Science Research Center, Kyung-Hee University) Lee, Hye-Jung (Acupuncture & Meridian Science Research Center, Kyung-Hee University) Kim, Young-Suk (Department of Oriental Internal Medicine, College of Oriental Medicine, Kyung-Hee University) Shim, In-Sop (Department of Integrative Medicine, The Catholic University of Korea) Park, Hi-Joon (Acupuncture & Meridian Science Research Center, Kyung-Hee University) Choi, Won-Ju (Department of Oriental Medicine, Dongkuk University) Kim, Jang-Hyun (Department of Oriental Medicine, Dongkuk University) Hahm, Dae-Hyun (Acupuncture & Meridian Science Research Center, Kyung-Hee University)
저널정보
경희한의학연구센터 Oriental pharmacy and experimental medicine Oriental pharmacy and experimental medicine 제7권 제5호
발행연도
2008.1
수록면
501 - 508 (8page)

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Anti-nociceptive and anti-inflammatory effects of Clematidis Radix (CR)-distillates were investigated in three different pain animal models. Highly purified distillate of CR was injected to Zusanli (ST36) acupoint, called CR herb-acupuncture in the Korean traditional medicine. In tail flick latency test, the CR herb-acupuncture treatment did not show a significant effect of relieving acute phasic pain. To investigate the anti-inflammatory effect of CR herb-acupuncture, inflammatory pain was induced by subcutaneous injection of formalin to the plantar tissue or intra-articular injection of carrageenan to the tibio-tarsal joint in the rats. And the medicinal effect of CR herb-acupuncture was evaluated by analyzing pain behavior such as licking or biting behavior, or by measuring weight distribution ratio between two foot and ankle circumference. In the rat formalin test, the analgesic effect of CR herb-acupuncture was more pronounced in the late phase (for 20 min after the early phase) than in the early phase (for the first 10 min post formalin injection). It also significantly alleviated the carrageenan-induced monoarthritis, in terms of weight distribution ratio and ankle edema. These results revealed that CR herb-acupuncture was effective to treat the inflammatory pain and could be used as an analgesic treatment with an antiinflammatory effect.

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