Cytotoxic and antioxidant properties of four plants belonging to the genus Solanum

Dongre, Santoshkumar H.; Badami, Shrishailappa; Godavarthi, Ashok; S., Mahendran; P., Vijayan; B., Suresh

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자료유형: 학술저널

저자정보: Dongre, Santoshkumar H. (J. S. S. College of Pharmacy) Badami, Shrishailappa (J. S. S. College of Pharmacy) Godavarthi, Ashok (J. S. S. College of Pharmacy) S., Mahendran (J. S. S. College of Pharmacy) P., Vijayan (J. S. S. College of Pharmacy) B., Suresh (J. S. S. College of Pharmacy)

저널정보: 경희한의학연구센터 Oriental pharmacy and experimental medicine Oriental pharmacy and experimental medicine 제8권 제1호

발행연도: 2008.1

수록면: 86 - 92 (7page)

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The aim of the study was to evaluate in vitro antioxidant and cytotoxic activities of the methanolic extracts of leaves of Solanum sisymbrifolium, Solanum anguivi multiflora, Solanum barbisetum and Solanum jasminoides. In the in vitro antioxidant screening using ABTS [2,2'-azino-bis (3-ethylbenzo-thiazoline-6-sulphonic acid) diammonium salt] method, the methanol extracts of Solanum jasminoides, Solanum barbisetum and Solanum anguivi multiflora exhibited potent antioxidant activity with $IC_{50}$ values 31.25 $\pm$ 0.35, 40.33 $\pm$ 0.57 and 54.33 $\pm$ 0.57 ${\mu}g$/ml, respectively. Solanum barbisetum also showed potent activity in DPPH [1,1-diphenyl-2-picryl hydrazyl] method with an $IC_{50}$ value of 55.33 $\pm$ 1.66 ${\mu}g/ml. In the cytotoxicity studies, the methanol extract of Solanum barbisetum exhibited moderate activity against Vero, HEp-2, HeLa and A-549 cell lines with $IC_{50}$ values in the range of 83.30 - 127.30 ${\mu}g$/ml. Solanum anguivi multiflora extract also showed moderate activity against Hep-2 cell line with $IC_{50}$ value of 80.13 ${\mu}g$/ml. Solanum barbisetum possessing both the activities requires further investigation.

#Solanum #Cytotoxicity #Free radical

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