지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 108 - 112 (5page)
이용수
초록· 키워드
오류제보하기
Alzheimer's disease(AD) is a neurodegenerative disorder characterized pathologically by senile plaques, neurofibrillary tangles, and synapse loss. Especially, extracellular beta-amyloid (Abeta) deposition is a major pathological hallmark of Alzheimer's disease (AD). In AD senile plaques, high level of iron and car-bonylated Abeta were detected. Iron has a Lewis acid property which can increase the electrophilicity of carbonyls, which may react catalytically with nucleophiles, such as amines. Hence, this study investigated whether or not iron could promote the carbonylation of amine with malondialdehyde (MDA) in the physiological condition. As the basic study, we examined that iron might promote the conjugation reaction between propylamine, monoamine molecule and MDA in the physiological condition. As the concentration of iron increased, the fluorescence intensity produced from the conjugation reaction increased in a dose-dependent manner. Instead of propylamine, we applied the same reaction condition to Abeta 1-40 peptide, one of major components founded in AD senile plaques for the conjugation reaction. As the result, the fluorescence intensity produced from the conjugation reaction between Abeta 1-40 peptide and MDA showed the similar trend to that of the reaction used with propylamine. This study suggests that iron can accelerate the conjugation reaction of MDA to Abeta 1-40 peptide and play an another important role in deterioration of AD brain.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
REGULATION OF BETA-AMYLOID-STIMULATED PROINFLAMMATORY RESPONSES VIA MITOGEN ACTIVATED PROTEIN KINASES AND REDOX SENSITIVE TRANSCRIPTION FACTORS
대한약학회 학술대회
2002 .01
-
Expression of TNF-$\alpha$ in rat microglia by ginsenoside Rb1
대한약학회 학술대회
2003 .01
-
Effect of iron-nanoparticles and iron-microparticles on erythropoiesis and iron-storage in iron-deficiency anemic mice
한국실험동물학회 학술발표대회 논문집
2012 .08
-
SY-5. Development of Rodent Models for Research of Amyloid Containing Senile Plaques in Alzheimer's Disease
한국실험동물학회 학술발표대회 논문집
1993 .10
-
Ginsenoside Rg3 enhances phagocytosis of microglia when activated by $\beta$-amyloid in rat primary culture
대한약학회 학술대회
2003 .01
-
신경계 질환에서 철 관련 자기공명영상 기법의 활용
Annals of Clinical Neurophysiology
2014 .01
-
Comparison of the Efficacies of Parenteral Iron Sucrose and Oral Iron Sulfate for Anemic Patients with Inflammatory Bowel Disease in Korea
Gut and Liver
2016 .01
-
Fe$^{59}$와 Cr$^{51}$ 동시표식법에 의한 각종질환 철대사 및 적혈구수명에 관한 연구
대한방사선의학회지
1966 .01
-
Biomarkers Predicting Alzheimer’s Disease in Cognitively Normal Aging
Journal of Clinical Neurology
2011 .01
-
Comparison in Bioavailability of orally administered Iron-nanoparticles and Iron-microparticles in Iron-deficiency Anemic(IDA) Mice
한국실험동물학회 학술발표대회 논문집
2013 .08
-
정상 성인과 Alzheimer병 환자 대뇌에서 주요 Gangliosides의 발현
Journal of Pathology and Translational Medicine
2002 .01
-
Iron deficiency increases blood concentrations of neurotoxic metals in children
Clinical and Experimental Pediatrics
2014 .01
-
Ginsenoside Rg3 inhibits the production of interleukin-1$\beta$, tumor necrosis factor-$\alpha$, and nitric oxide in rat microglia
대한약학회 학술대회
2003 .01
-
다시 보는 알츠하이머병의 아밀로이드 가설
생물치료정신의학
2014 .12
-
Mechanisms of Amyloid-β Peptide Clearance: Potential Therapeutic Targets for Alzheimer's Disease
Biomolecules & Therapeutics(구 응용약물학회지)
2012 .01
-
A Simple Method for Conjugation Between Ginsenoside Rf and Bovine Serum Albumin
Journal of Ginseng Research
1999 .03
-
철 석출장치에 의한 폐수 중의 인 제거 특성
한국환경보건학회지
2006 .01
-
A specific butyrylcholinesterase inhibitor from the fruits of Evodia officinalis
대한약학회 학술대회
2002 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0