지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Cyanobacteria are well known for their production of a multitude of highly toxic and / or allelopathic compounds. Among the photosynthetic microorganisms, cyanobacteria, belonging to the genus Nostoc are regarded as good candidate for producing biologically active secondary metabolites which are highly toxic to humans and other animals. Since so many reports have been published on the poisoning of different animals from drinking water contaminated with cyanobacteria toxins, it might be assumed that bioactive compounds are found only in aquatic species causes toxicity. However, the discovery of several dead dogs, mice, ducks, and fish around paddy fields, prompted us to study the toxic compounds in a strain of Nostoc which is most abundant in the paddy fields of Iran, using polymerase chain reaction and liquid chromatography coupled with a diode array detector and mass spectrophotometer. Results of molecular analysis demonstrated that the ASN_M strain contains the nosF gene. Also, the result of ion chromatograms and $MS^2$ fragmentation patterns showed that while there were three different peptidic compound classes (anabaenopeptin, cryptophycin, and nostocyclopeptides), there were no signs of the presence of anatoxin-a, homoanatoxin-a, hassallidin or microcystins. Moreover, a remarkable antifungal activity was identified in the methanolic extracts. Based on the results, this study suggests that three diverse groups of potentially bioactive compounds might account for the death of these animals. This case is the first documented incident of toxicity from aquatic cyanobacteria related intoxication in dogs, mice, and aquatic organisms in Iran.
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참고문헌 (37)
참고문헌 신청
Becker, J. E. / 2004 / Cloning, sequencing, and biochemical characterization of the nostocyclopeptide biosynthetic gene cluster: molecular basis for imine macrocyclization / Gene 325:35~42
Bui, H. T. N. / 2007 / Carbamidocyclophanes A-E, chlorinated paracyclophanes with cytotoxic and antibiotic activity from the vietnamese cyanobacterium Nostoc sp / J. Nat. Prod 4:499~503
Dembitsky, V. M. / 2005 / Metabolites produced by nitrogen-fixing Nostoc species / Folia Microbiol 50:363~391
Desikachary, T. V. / 1959 / Cyanophyta :686
Dittmann, E. / 2001 / Molecular biology of peptide and polyketide biosynthesis in cyanobacteria / Appl. Microbiol. Biotechnol 57:467~473
Bui, H. T. N. / 2007 / Carbamidocyclophanes A-E, chlorinated paracyclophanes with cytotoxic and antibiotic activity from the vietnamese cyanobacterium Nostoc sp / J. Nat. Prod 4:499~503
Dembitsky, V. M. / 2005 / Metabolites produced by nitrogen-fixing Nostoc species / Folia Microbiol 50:363~391
Desikachary, T. V. / 1959 / Cyanophyta :686
Dittmann, E. / 2001 / Molecular biology of peptide and polyketide biosynthesis in cyanobacteria / Appl. Microbiol. Biotechnol 57:467~473
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