지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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To develop effective and safe acne vulgaris therapies with a continuing demand for new solutions, we investigated unique efficacy of an antibacterial agent from marine brown alga Eisenia bicyclis in treating acne vulgaris. The methanolic extract of E. bicyclis exhibited potential antibacterial activity against acne-related bacteria. The ethyl acetate fraction showed the strongest antibacterial activity against the bacteria among solvent fractions. Six compounds (1-6), previously isolated from the ethyl acetate fraction of E. bicyclis, were evaluated for antibacterial activity against acne-related bacteria. Among them, compound 2 (fucofuroeckol-A [FF]) exhibited the highest antibacterial activity against acne-related bacteria with a minimum inhibitory concentration (MIC) ranging from 32 to $128{\mu}g\;mL^{-1}$. Furthermore, FF clearly reversed the high-level erythromycin and lincomycin resistance of Propionibacterium acnes. The MIC values of erythromycin against P. acnes were dramatically reduced from 2,048 to $1.0{\mu}g\;mL^{-1}$ in combination with MIC of FF ($64{\mu}g\;mL^{-1}$). The fractional inhibitory concentration indices of erythromycin and lincomycin were measured from 0.500 to 0.751 in combination with 32 or $64{\mu}g\;mL^{-1}$ of FF against all tested P. acnes strains, suggesting that FF-erythromycin and FF-lincomycin combinations exert a weak synergistic effect against P. acnes. The results of this study suggest that the compounds derived from E. bicyclis can be a potential source of natural antibacterial agents and a pharmaceutical component against acnerelated bacteria.
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참고문헌 (39)
참고문헌 신청
Afolayan, A. J. / 2003 / Extracts from the shoots of Arctotis arctotoides inhibit the growth of bacteria and fungi / Pharm. Biol 41:22~25
Bo Ra Ahn / 2012 / Neuroprotective Effect of Edible Brown Alga Eisenia bicyclis on Amyloid Beta Peptide-induced Toxicity in PC12 Cells / Archives of Pharmacal Research 35(11):1989~1998
Choi, J. -G. / 2010 / Antibacterial activity of Ecklonia cava against methicillin-resistant Staphylococcus aureus and Salmonella spp / Foodborne Pathog. Dis 7:435~441
Choi, J. -S. / 2011 / In vitro antibacterial and anti-inflammatory properties of seaweed extracts against acne inducing bacteria, Propionibacterium acnes / J. Environ. Biol 32:313~318
Clinical and Laboratory Standards Institute / 2006 / Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically: Approved standard, 8th ed / CLSI :68
Bo Ra Ahn / 2012 / Neuroprotective Effect of Edible Brown Alga Eisenia bicyclis on Amyloid Beta Peptide-induced Toxicity in PC12 Cells / Archives of Pharmacal Research 35(11):1989~1998
Choi, J. -G. / 2010 / Antibacterial activity of Ecklonia cava against methicillin-resistant Staphylococcus aureus and Salmonella spp / Foodborne Pathog. Dis 7:435~441
Choi, J. -S. / 2011 / In vitro antibacterial and anti-inflammatory properties of seaweed extracts against acne inducing bacteria, Propionibacterium acnes / J. Environ. Biol 32:313~318
Clinical and Laboratory Standards Institute / 2006 / Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically: Approved standard, 8th ed / CLSI :68
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