지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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Ecklonia cava is a common edible brown algae that is plentiful in Jeju Island of Republic of Korea. Polyphenols from E. cava have strong anti-inflammatory activity. However, a large number of the by-products from E. cava processing are discarded. In the present study, to utilize these by-products, we assessed the anti-inflammatory activity of the polyphenol-rich fraction (PRF) from E. cava processing by-product (EPB) in lipopolysaccharide (LPS)-induced RAW264.7 macrophage cells. Four compounds, namely eckol, eckstolonol, dieckol, and phlorofucofuroeckol-A, were isolated and identified from PRF. We found that PRF suppressed the production of nitric oxide (NO), inducible nitric oxide synthase, and cyclooxygenase-2 in the LPS-induced cells. Furthermore, the protective effect of PRF was investigated in vivo in LPS-stimulated inflammation zebrafish model. PRF had a protective effect against LPS-stimulated toxicity in zebrafish embryos. In addition, PRF inhibited LPS-stimulated reactive oxygen species and NO generation. According to the results, PRF isolated from EPB could be used as a beneficial anti-inflammatory agent, instead of discard.
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참고문헌 (46)
참고문헌 신청
Ahn, K. S. / 2005 / Inhibition of inducible nitric oxide synthase and cyclooxygenase II by Platycodon grandiflorum saponins via suppression of nuclear factor-κB activation in RAW 264.7 cells / Life Sci 76:2315~2328
Bölck, B. / 2014 / Detection of key enzymes, free radical reaction products and activated signaling molecules as biomarkers of cell damage induced by benzo[a]pyrene in human keratinocytes / Toxicol. In Vitro 28:875~884
최지일 / 2012 / Effects of γ-Aminobutyric Acid (GABA)-Enriched Sea Tangle Laminaria japonica Extract on Lipopolysaccharide-Induced Inflammation in Mouse Macrophage (RAW 264.7) Cells / Fisheries and Aquatic Sciences 15(4):293~297
Conforti, F. / 2008 / In vivo anti-inflammatory and in vitro antioxidant activities of Mediterranean dietary plants / J. Ethnopharmacol 116:144~151
Dewanjee, S. / 2013 / Potential anti-inflammatory effect of Leea macrophylla Roxb. leaves: a wild edible plant / Food Chem. Toxicol 59:514~520
Bölck, B. / 2014 / Detection of key enzymes, free radical reaction products and activated signaling molecules as biomarkers of cell damage induced by benzo[a]pyrene in human keratinocytes / Toxicol. In Vitro 28:875~884
최지일 / 2012 / Effects of γ-Aminobutyric Acid (GABA)-Enriched Sea Tangle Laminaria japonica Extract on Lipopolysaccharide-Induced Inflammation in Mouse Macrophage (RAW 264.7) Cells / Fisheries and Aquatic Sciences 15(4):293~297
Conforti, F. / 2008 / In vivo anti-inflammatory and in vitro antioxidant activities of Mediterranean dietary plants / J. Ethnopharmacol 116:144~151
Dewanjee, S. / 2013 / Potential anti-inflammatory effect of Leea macrophylla Roxb. leaves: a wild edible plant / Food Chem. Toxicol 59:514~520
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