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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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Despite the extensive literature on marine algae over the past few decades, a paucity of published research and studies exists on red algae. The purpose of this study was to evaluate the potential therapeutic properties of the ethanol extract of the red alga Callophyllis japonica against lipopolysaccharide (LPS)-stimulated macrophage inflammation. The C. japonica extract (CJE) significantly inhibited the nitric oxide (NO) production and the induced dose-dependent reduction of the protein and mRNA levels of inducible nitric oxide synthase and cyclooxygenase-2. Additionally, the CJE reduced the mRNA levels of inflammatory cytokines, including tumor necrosis factor-${\alpha}$, interleukin (IL)-$1{\beta}$, and IL-6. We investigated the mechanism by which the CJE inhibits NO by examining the level of mitogen-activated protein kinases (MAPKs) activation, which is an inflammation-induced signaling pathway in macrophages. The CJE significantly suppressed the LPS-induced phosphorylation of c-Jun N-terminal kinase, extracellular signal-regulated kinase and p38 MAPK. Taken together, the results of this study demonstrate that the CJE inhibits LPS-induced inflammation by blocking the MAPK pathway in macrophages.
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참고문헌 (42)
참고문헌 신청
Aggarwal, B. B. / 1996 / Tumor necrosis factors: developments during the last decade / Eur. Cytokine Netw 7:93~124
Ajizian, S. J. / 1999 / Specific inhibitors of p38 and extracellular signal-regulated kinase mitogen-activated protein kinase pathways block inducible nitric oxide synthase and tumor necrosis factor accumulation in murine macrophages stimulated with lipopolysaccharide and interferon-gamma / J. Infect. Dis 179:939~944
Akira, S. / 2001 / Toll-like receptors: critical proteins linking innate and acquired immunity / Nat. Immunol 2:675~680
Athanasiadis, A / 2003 / Taxonomy of Rhodophyta with particular reference to Mediterranean species / Bocconea 16:193~198
Bhat, N. R. / 1998 / Extracellular signal-regulated kinase and p38 subgroups of mitogen-activated protein kinases regulate inducible nitric oxide synthase and tumor necrosis factor-alpha gene expression in endotoxin-stimulated primary glial cultures / J. Neurosci 18:1633~1641
Ajizian, S. J. / 1999 / Specific inhibitors of p38 and extracellular signal-regulated kinase mitogen-activated protein kinase pathways block inducible nitric oxide synthase and tumor necrosis factor accumulation in murine macrophages stimulated with lipopolysaccharide and interferon-gamma / J. Infect. Dis 179:939~944
Akira, S. / 2001 / Toll-like receptors: critical proteins linking innate and acquired immunity / Nat. Immunol 2:675~680
Athanasiadis, A / 2003 / Taxonomy of Rhodophyta with particular reference to Mediterranean species / Bocconea 16:193~198
Bhat, N. R. / 1998 / Extracellular signal-regulated kinase and p38 subgroups of mitogen-activated protein kinases regulate inducible nitric oxide synthase and tumor necrosis factor-alpha gene expression in endotoxin-stimulated primary glial cultures / J. Neurosci 18:1633~1641
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