지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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In this study, four compounds isolated from the red alga Laurencia snackeyi were evaluated for their potential anti-inflammatory effect in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages. These compounds were tested for their inhibitory effects on nitric oxide (NO) production in LPS-stimulated RAW 264.7 cells. Since $5{\beta}$-hydroxypalisadin B showed the best activity it was further tested for the production of prostaglandin-$E_2$ ($PGE_2$), expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2), the release of pro-inflammatory cytokines tumor necrotic factor-alpha (TNF-${\alpha}$), interleukin-$1{\beta}$ (IL-$1{\beta}$), and interleukin-6 (IL-6). $5{\beta}$-Hydroxypalisadin B significantly reduced the $PGE_2$ release and suppressed the iNOS and COX-2 expression in LPS-stimulated RAW 264.7 cells. It also significantly reduced the release of pro-inflammatory cytokines TNF-${\alpha}$, IL-$1{\beta}$, and IL-6. These findings provide the first evidence of anti-inflammatory potential of $5{\beta}$-hydroxypalisadin B isolated from the red alga L. snackeyi and hence, it could be exploited as an active ingredient in pharmaceutical, nutraceutical and functional food applications.
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참고문헌 (26)
참고문헌 신청
Ahmad, N. / 2002 / Regulation of cyclooxygenase-2 by nitric oxide in activated hepatic macrophages during acute endotoxemia / J. Leukoc. Biol 71:1005~1011
Chang, Y. C. / 2006 / Lipoteichoic acid-induced nitric oxide synthase expression in RAW 264.7 macrophages is mediated by cyclooxygenase-2, prostaglandin E2, protein kinase A, p38 MAPK, and nuclear factor-κB pathways / Cell Signal 18:1235~1243
Cho, J. Y. / 2000 / In vitro anti-inflammatory effects of cynaropicrin, a sesquiterpene lactone, from Saussurea lappa / Eur. J. Pharmacol 398:399~407
Heo, S. -J. / 2010 / Evaluation of anti-inflammatory effect of fucoxanthin isolated from brown algae in lipopolysaccharide-stimulated RAW 264.7 macrophages / Food Chem. Toxicol 48:2045~205
Hernández-Ledesma, B. / 2009 / Antioxidant and anti-inflammatory properties of cancer preventive peptide lunasin in RAW 264.7 macrophages / Biochem. Biophys. Res. Commun 390:803~808
Chang, Y. C. / 2006 / Lipoteichoic acid-induced nitric oxide synthase expression in RAW 264.7 macrophages is mediated by cyclooxygenase-2, prostaglandin E2, protein kinase A, p38 MAPK, and nuclear factor-κB pathways / Cell Signal 18:1235~1243
Cho, J. Y. / 2000 / In vitro anti-inflammatory effects of cynaropicrin, a sesquiterpene lactone, from Saussurea lappa / Eur. J. Pharmacol 398:399~407
Heo, S. -J. / 2010 / Evaluation of anti-inflammatory effect of fucoxanthin isolated from brown algae in lipopolysaccharide-stimulated RAW 264.7 macrophages / Food Chem. Toxicol 48:2045~205
Hernández-Ledesma, B. / 2009 / Antioxidant and anti-inflammatory properties of cancer preventive peptide lunasin in RAW 264.7 macrophages / Biochem. Biophys. Res. Commun 390:803~808
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