지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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A monoterpene lactone, loliolide was successively isolated from brown seaweed, Sargassum ringgoldianum subsp. coreanum using column chromatography and high-performance liquid chromatography. The structure of the isolated compound was determined by comparison of EIMS and NMR spectral data with the previously published data. The antioxidant activities of loliolide were also evaluated by DPPH and $H_2O_2$ radical and intracellular reactive oxygen species scavenging assays, and it showed moderate activities in all antioxidant assays. Furthermore, loliolide was found to exert positive dose-dependent effects in the protective effects against $H_2O_2$-induced cell damage which were determined via MTT, Hoechst staining assays and cell cycle analysis. This is the first study on chemical constituent of this seaweed according to our best knowledge. These results clearly indicated that loliolide isolated from Sargassum ringgoldianum subsp. coreanum can protect the cells against $H_2O_2$-induced cell damage or apoptosis.
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참고문헌 (23)
참고문헌 신청
You-Jin Jeon / 2005 / Screening for Angiotensin 1-Converting Enzyme Inhibitory Activity of Ecklonia cava / Preventive Nutrition and Food Science 10(2):134~139
Athukorala, Y. / 2007 / Anticoagulant activity of marine green and brown algae collected from Jeju Island in Korea / Bioresour. Technol 98:1711~1716
Blois, M. S. / 1958 / Antioxidant determination by the use of a stable free radical / Nature 181:1199~1200
Chang, H. W. / 2008 / Monoglycerides from the brown alga Sargassum sagamianum: Isolation, synthesis, and biological activity / BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 18:3589~3592
Gschwind, M. / 1995 / Apoptotic cell death induced by β-amyloid 1-42 peptide is cell type dependent / J. Neurochem 65:292~300
Athukorala, Y. / 2007 / Anticoagulant activity of marine green and brown algae collected from Jeju Island in Korea / Bioresour. Technol 98:1711~1716
Blois, M. S. / 1958 / Antioxidant determination by the use of a stable free radical / Nature 181:1199~1200
Chang, H. W. / 2008 / Monoglycerides from the brown alga Sargassum sagamianum: Isolation, synthesis, and biological activity / BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 18:3589~3592
Gschwind, M. / 1995 / Apoptotic cell death induced by β-amyloid 1-42 peptide is cell type dependent / J. Neurochem 65:292~300
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