지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 23 - 26 (4page)
이용수
초록· 키워드
오류제보하기
Thrombophilia refers to inherited or acquired hemostatic disorders that result in a predisposition to blood clot formation. When combined with the hypercoagulable state that is characteristic of pregnancy, there is an increased risk of severe and recurrent pregnancy complications. Activated protein C resistance caused by factor V Leiden (FVL) mutation is known to be the most common cause of inherited thrombophilia in Caucasian population. FVL mutation has been related to pregnancy complications associated with hypercoagulation, e.g. miscarriage, intrauterine fetal demise, placental abruption, and intrauterine growth retardation. Although the FVL mutation is easily detected using molecular DNA techniques, patients who are heterozygous for this disorder often remain asymptomatic until they develop a concurrent prothrombotic condition. Because there are potentially serious effects of FVL mutation for pregnancy, and because effective treatment strategies exist, early detection and treatment of this condition might be considered.
목차
등록된 정보가 없습니다.
참고문헌 (17)
참고문헌 신청
Jaslow CR / 2010 / Diagnostic factors identified in 1020 women with two versus three or more recurrent pregnancy losses / Fertil Steril 93:1234~1243
Rai R / 2006 / Recurrent miscarriage / Lancet 368:601~611
Brenner B / 1999 / Inherited thrombophilia and pregnancy loss / Thromb Haemost 82:634~640
Younis JS / 1997 / Familial thrombophilia--the scientific rationale for thrombophylaxis in recurrent pregnancy loss? / Hum Reprod 12:1389~1390
Dahlbäck B / 1994 / Inherited resistance to activated protein C, a major cause of venous thrombosis, is due to a mutation in the factor V gene / Haemostasis 24:139~151
Rai R / 2006 / Recurrent miscarriage / Lancet 368:601~611
Brenner B / 1999 / Inherited thrombophilia and pregnancy loss / Thromb Haemost 82:634~640
Younis JS / 1997 / Familial thrombophilia--the scientific rationale for thrombophylaxis in recurrent pregnancy loss? / Hum Reprod 12:1389~1390
Dahlbäck B / 1994 / Inherited resistance to activated protein C, a major cause of venous thrombosis, is due to a mutation in the factor V gene / Haemostasis 24:139~151
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