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논문 기본 정보

자료유형
학술저널
저자정보
Kanezaki, Hiroshi (Department of Energy and Hydrocarbon Chemistry, Graduate School of Engineering, Kyoto University) Nishimoto, Sei-Ichi (Department of Energy and Hydrocarbon Chemistry, Graduate School of Engineering, Kyoto University) Tanabe, Kazuhito (Department of Energy and Hydrocarbon Chemistry, Graduate School of Engineering, Kyoto University)
저널정보
한국광과학회 Rapid communication in photoscience : RCP Rapid communication in photoscience : RCP 제3권 제4호
발행연도
2014.1
수록면
79 - 80 (2page)

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We characterized the one-electron reduction of oligodeoxynucleotides with a 2-oxopropyl group on a thymine base ($d^{oxo}T$) and applied the reaction to the radiolytic activation of DNAzyme function. We designed a system in which the DNAzyme function of cleaving mRNA was suppressed by introduction of $d^{oxo}T$ into the strand of DNAzyme. Hypoxic X-irradiation led to recovery of the cleavage ability because the 2-oxopropyl group was removed to form unmodified DNAzyme. We characterized the DNAzyme function by monitoring the fluorescence change of fluorophore- and quencher-labeled target strands. We confirmed that the DNAzyme function could be regulated by hypoxic X-irradiation and the reaction of $d^{oxo}T$.

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