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자료유형
학술저널
저자정보
Ahn, Jongchan (Department of Biomedical Science, CHA University) Park, Seah (Department of Biomedical Science, CHA University) Cha, Byung-Hyun (Department of Biomedical Science, CHA University) Kim, Jae Hwan (Department of Biomedical Science, CHA University) Park, Hansoo (Department of Integrative Engineering, Chung-Ang University) Joung, Yoon Ki (Department of Biomedical Science, CHA University) Han, Inbo (Department of Neurosurgery, Bundang Medical Center, CHA University) Lee, Soo-Hong (Department of Biomedical Science, CHA University)
저널정보
테크노프레스 Biomaterials and biomedical engineering Biomaterials and biomedical engineering 제1권 제3호
발행연도
2014.1
수록면
151 - 162 (12page)

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Genetically-modified mesenchymal stem cells (GM-MSCs) have emerged as promising therapeutic tools for orthopedic degenerative diseases. GM-MSCs have been widely reported that they are able to increase bone and cartilage tissue regeneration not only by secreting transgene products such as growth factors in a long-term manner, also by inducing MSCs into tissue-specific cells. For example, MSCs modified with BMP-2 gene increased secretion of BMP-2 protein resulting in enhancement of bone regeneration, while MSCs with TGF-b gene did cartilage regeneration. In this review, we introduce several growth factors for gene delivery to MSCs and strategies for bone and cartilage tissue regeneration using GM-MSCs. Furthermore, we describe strategies for strengthening GM-MSCs to more intensively induce tissue regeneration by co-delivery system of multiple genes.

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