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학술저널
저자정보
Chen, Yanfei (Department of Industrial Engineering, University of Pittsburgh) Jankowitz, Brian T. (Department of Neurological Surgery, University of Pittsburgh Medical Center) Cho, Sung Kwon (Department of Mechanical Engineering and Materials Science, University of Pittsburgh) Yeo, Woon-Hong (Department of Mechanical and Nuclear Engineering, Center for Rehabilitation Science and Engineering, Virginia Commonwealth University) Chun, Youngjae (Department of Industrial Engineering, University of Pittsburgh)
저널정보
테크노프레스 Biomaterials and biomedical engineering Biomaterials and biomedical engineering 제2권 제2호
발행연도
2015.1
수록면
71 - 84 (14page)

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A low-profile flow sensor has been designed, fabricated, and characterized to demonstrate the feasibility for monitoring hemodynamics in cerebral aneurysm. The prototype device is composed of three micro-membranes ($500-{\mu}m$-thick polyurethane film with $6-{\mu}m$-thick layers of nitinol above and below). A novel super-hydrophilic surface treatment offers excellent hemocompatibility for the thin nitinol electrode. A computational study of the deformable mechanics optimizes the design of the flow sensor and the analysis of computational fluid dynamics estimates the flow and pressure profiles within the simulated aneurysm sac. Experimental studies demonstrate the feasibility of the device to monitor intra-aneurysmal hemodynamics in a blood vessel. The mechanical compression test shows the linear relationship between the applied force and the measured capacitance change. Analytical calculation of the resonant frequency shift due to the compression force agrees well with the experimental results. The results have the potential to address important unmet needs in wireless monitoring of intra-aneurysm hemodynamic quiescence.

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