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자료유형
학술저널
저자정보
Al-Jumaily, Ahmed M. (Institute of Biomedical Technologies, Auckland University of Technology) Mathur, Meha (Institute of Biomedical Technologies, Auckland University of Technology) Cairns, Simeon (Institute of Biomedical Technologies, Auckland University of Technology)
저널정보
테크노프레스 Biomaterials and biomedical engineering Biomaterials and biomedical engineering 제2권 제4호
발행연도
2015.1
수록면
225 - 235 (11page)

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Treatments for asthma are largely pharmaceutical, with some therapies also utilising alternative breathing techniques. The objective of both medical and alternative methods is to relax contracted airway smooth muscle (ASM). In normal subjects, tidal breathing- and deep inspiration-oscillations are believed to have a bronchodilatory effect. Similarly, application of length oscillations to isolated, contracted ASM also elicits muscle relaxation. As a means of investigating more-effective alternative treatment methods for contracted airways, we analyse the combined effects of bronchodilators and length oscillations on isolated, contracted ASM. The contractile state of the muscle tissue prior to treatment is of primary interest. Thereafter, the effect of applying a combination of small superimposed length oscillations with tidal breathing-like oscillations to ASM is studied alone and in combination with a common bronchodilator, isoproterenol (ISO). This work suggests that relaxation of isolated, contracted ASM following application of combined oscillations and ISO is larger than treatments of either combined oscillations or ISO alone. Further, the observed oscillation-associated relaxation is found to be amplitude- rather than frequency-dependent. This study gives additional insight into the role of oscillations and bronchodilators on contracted airways.

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