Performance of the R-way Colposcopic Evaluation System in Cervical Cancer Screening

Zhao, Jian; Zhang, Xi; Chen, Rui; Zhao, Yu-Qian; Wang, Ting-Ting; He, Shan; Qiao, You-Lin

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자료유형: 학술저널

저자정보: Zhao, Jian (Department of Gynaecology and Obstetrics, Peking University First Hospital, Peking University Health Science Center, Peking University) Zhang, Xi (Department of Cancer Epidemiology, National Cancer Center, Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College) Chen, Rui (Beijing Tsinghua Changguang Hospital, Capital Medical University) Zhao, Yu-Qian (Department of Cancer Epidemiology, National Cancer Center, Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College) Wang, Ting-Ting (Chinese Center For Disease Control And Prevention) He, Shan (Beijing Luhe Hospital, Capital Medical University) Qiao, You-Lin (Department of Cancer Epidemiology, National Cancer Center, Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제16권 제10호

발행연도: 2015.1

수록면: 4,223 - 4,228 (6page)

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Objective: To investigate the diagnostic value of the R-way colposcopic evaluation system (R-way system) in cervical cancer screening. Materials and Methods: Between August 2013 and August 2014, a total of 1,059 cases referred to colposcopy in Peking University First Hospital were studied using both the R-way system and conventional colposcopy. Our study evaluated and compared the diagnostic ability of the two methods in detecting high-grade lesions and cervical cancer (hereinafter called CIN2+). Evaluation indicators including sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), Youden index and the area under the curve (AUC) of the receiver operating characteristic (ROC) were calculated. Results: The R-way system had a slightly lower specificity (94.5%) than conventional colposcopy (96.0%) for CIN2+ detection (P=0.181). However, the sensitivity (77.8%) was significantly higher than with the conventional colposcopic method (46.6%) (${\chi}^2=64.351$, P<0.001). In addition, the AUC of the ROC for CIN2+ detection using the R-way system (0.839) was larger than that with conventional colposcopy (0.731) (Z=4.348, P<0.001). If preliminary result had been drawn from cervical exfoliated cytology before colposcopy referral, combination of the R-way system with cytology could increase the sensitivity to 93.9% for CIN2+ detection (excluding ASCUS\LSIL), confirmed by multipoint biopsy or ECC. Conclusions: The diagnostic value of the R-way evaluation system is higher than that of conventional colposcopic evaluation in cervical cancer screening. Moreover, taking the ease of use and standardized quality control management into account, the R-way system is highly preferable.

#R-way colposcopic evaluation system #conventional colposcopic examination #cervical cancer screening

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Zhao, Jian

소속기관 Department of Gynaecology and Obstetrics, Peking University First Hospital, Peking University Health