Adjuvant Radiotherapy for Gastric Carcinoma: 10 years Follow-up of 244 cases from a Single Institution

Misirlioglu, Hasan Cem; Coskun-Breuneval, Mehtap; Kucukpilakci, Bulent; Ugur, Vahide Isil; Elgin, Yesim; Demirkasimoglu, Taciser; Kara, Sakire Pinar; Ozgen, Aytul; Sanri, Ergun; Guney, Yildiz

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자료유형: 학술저널

저자정보: Misirlioglu, Hasan Cem (Department of Radiation Oncology, Ankara Oncology Hospital) Coskun-Breuneval, Mehtap (Department of Medical Oncology, University of Lausanne) Kucukpilakci, Bulent (Department of Radiation Oncology, Ankara Oncology Hospital) Ugur, Vahide Isil (Department of Radiation Oncology, Ankara Oncology Hospital) Elgin, Yesim (Department of Radiation Oncology, Ankara Oncology Hospital) Demirkasimoglu, Taciser (Department of Radiation Oncology, Ankara Oncology Hospital) Kara, Sakire Pinar (Department of Radiation Oncology, Ankara Oncology Hospital) Ozgen, Aytul (Department of Radiation Oncology, Ankara Oncology Hospital) Sanri, Ergun (Department of Radiation Oncology, Ankara Oncology Hospital) Guney, Yildiz (Department of Radiation Oncology, Ankara Oncology Hospital)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제15권 제20호

발행연도: 2014.1

수록면: 8,871 - 8,876 (6page)

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Background: Postoperative chemoradiotherapy (CRT) of gastric carcinoma improves survival among high-risk patients. This study was undertaken to analyse long-term survival probability and the impact of certain covariates on the survival outcome in affected individuals. Materials and Methods: Between January 2000 and December 2005, 244 patients with gastric cancer underwent adjuvant radiotherapy (RT) in our institution. Data were retrieved retrospectively from patient files and analysed with SPSS version 21.0. Results: A total of 244 cases, with a male to female ratio of 2.2:1, were enrolled in the study. The median age of the patients was 52 years (range, 20-78 years). Surgical margin status was positive or close in 72 (33%) out of 220 patients. Postoperative adjuvant RT dose was 46 Gy. Median follow-up was 99 months (range, 79-132 months) and 23 months (range, 2-155 months) for surviving patients and all patients, respectively. Actuarial overall survival (OS) probability for 1-, 3-, 5- and 10-year was 79%, 37%, 24% and 16%, respectively. Actuarial progression free survival (PFS) probability was 69%, 34%, 23% and 16% in the same consecutive order. AJCC Stage I-II disease, subtotal gastrectomy and adjuvant CRT were significantly associated with improved OS and PFS in multivariate analyses. Surgical margin status or lymph node dissection type were not prognostic for survival. Conclusions: Postoperative CRT should be considered for all patients with high risk of recurrence after gastrectomy. Beside well-known prognostic factors such as stage, lymph node status and concurrent chemotherapy, the type of gastrectomy was an important prognostic factor in our series. With our findings we add to the discussion on the definition of required surgical margin for subtotal gastrectomy. We consider that our observations in gastric cancer patients in our clinic can be useful in the future randomised trials to point the way to improved outcomes.

#Gastric cancer #chemoradiotherapy #adjuvant radiotherapy #surgery #prognosis

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