Green Tea Polyphenol Protection Against 4-Nitroquinoline 1-Oxide-Induced Bone Marrow Lipid Peroxidation and Genotoxicity in Wistar Rats

Pandurangan, Ashok Kumar; Periasamy, Srinivasan; Anandasadagopan, Suresh Kumar; Ganapasam, Sudhandiran; Srinivasalu, Shyamala Devi Chennam

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자료유형: 학술저널

저자정보: Pandurangan, Ashok Kumar (Cell Biology Laboratory, Department of Advanced Biochemistry, University of Madras) Periasamy, Srinivasan (Cell Biology Laboratory, Department of Advanced Biochemistry, University of Madras) Anandasadagopan, Suresh Kumar (Cell Biology Laboratory, Department of Advanced Biochemistry, University of Madras) Ganapasam, Sudhandiran (Cell Biology Laboratory, Department of Advanced Biochemistry, University of Madras) Srinivasalu, Shyamala Devi Chennam (Cell Biology Laboratory, Department of Advanced Biochemistry, University of Madras)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제13권 제8호

발행연도: 2012.1

수록면: 4,107 - 4,112 (6page)

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4-Nitroquinoline 1-oxide (4-NQO) a potent oral carcinogen, widely used for induction of oral carcinogenesis, has been found to induce lipid peroxidation in vivo and in vitro. Green tea contains a high content of polyphenols, which are potent antioxidants. Thus green tea polyphenols (GTP) might be expected play a protective role against 4-NQO induced lipid peroxidation and bone marrow toxicity. In the present study, a dose of 200 mg of GTP/kg b.wt/day was given orally for a week, simultaneously animals received 0.2 ml of 0.5% 4-NQO in propylene glycol (5 mg/ml) injected intramuscularly for three times/week. Oxidants and antioxidants such as malendialdehyde (MDA) and thiols, glutathione peroxidase (GPx), glutathione reductase (GR), superoxide dismutase (SOD) and catalase (CAT) were significantly decreased in 4-NQO induced animals except MDA, and these parameters were brought back to near normalcy on treatment with GTP. The results suggest that GTP treatment offers significant protection against 4-NQO induced lipid peroxidation and bone marrow toxicity and might be a promising potential candidate for prevention of mutations leading to cancer.

#Green tea polyphenols #4-nitroquinoline 1-oxide #bone marrow #lipid peroxidation

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Pandurangan, Ashok Kumar

소속기관 Department of Nutrition and Dietetics, Faculty of Medicine and Health Sciences, Universiti Putra Mal