Asparagus Polysaccharide and Gum with Hepatic Artery Embolization Induces Tumor Growth and Inhibits Angiogenesis in an Orthotopic Hepatocellular Carcinoma Model

Weng, Ling-Ling; Xiang, Jian-Feng; Lin, Jin-Bo; Yi, Shang-Hui; Yang, Li-Tao; Li, Yi-Sheng; Zeng, Hao-Tao; Lin, Sheng-Ming; Xin, Dong-Wei; Zhao, Hai-Liang; Qiu, Shu-Qi; Chen, Tao; Zhang, Min-Guang

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자료유형: 학술저널

저자정보: Weng, Ling-Ling (Department of Radiology, Shanghai Municipal Hospital of Traditional Chinese Medicine [TCM] Affiliated to Shanghai University of TCM) Xiang, Jian-Feng (Rizhao Municipal Hospital of Traditional Chinese Medicine) Lin, Jin-Bo (Longgang Central Hospital, ENT hospital of Longgang Central Hospital, Otolaryngology Institute of Shenzhen University) Yi, Shang-Hui (Teaching and Research Section of Epidemiology, Hunan Normal University) Yang, Li-Tao (Longgang Central Hospital, ENT hospital of Longgang Central Hospital, Otolaryngology Institute of Shenzhen University) Li, Yi-Sheng (Longgang Central Hospital, ENT hospital of Longgang Central Hospital, Otolaryngology Institute of Shenzhen University) Zeng, Hao-Tao (Longgang Central Hospital, ENT hospital of Longgang Central Hospital, Otolaryngology Institute of Shenzhen University) Lin, Sheng-Ming (Department of Radiology, Shanghai Municipal Hospital of Traditional Chinese Medicine [TCM] Affiliated to Shanghai University of TCM) Xin, Dong-Wei (Department of Radiology, Shanghai Municipal Hospital of Traditional Chinese Medicine [TCM] Affiliated to Shanghai Unive) Zhao, Hai-Liang Qiu, Shu-Qi Chen, Tao Zhang, Min-Guang

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제15권 제24호

발행연도: 2014.1

수록면: 10,949 - 10,955 (7page)

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Liver cancer is one of leading digestive malignancies with high morbidity and mortality. There is an urgent need for the development of novel therapies for this deadly disease. It has been proven that asparagus polysaccharide, one of the most active derivates from the traditional medicine asparagus, possesses notable antitumor properties. However, little is known about the efficacy of asparagus polysaccharide as an adjuvant for liver cancer chemotherapy. Herein, we reported that asparagus polysaccharide and its embolic agent form, asparagus gum, significantly inhibited liver tumor growth with transcatheter arterial chemoembolization (TACE) therapy in an orthotopic hepatocellular carcinoma (HCC) tumor model, while significantly inhibiting angiogenesis and promoting tumor cell apoptosis. Moreover, asparagine gelatinous possessed immunomodulatory functions and showed little toxicity to the host. These results highlight the chemotherapeutic potential of asparagus polysaccharide and warrant a future focus on development as novel chemotherapeutic agent for liver cancer TACE therapy.

#Hepatocellular carcinoma #HCC) #asparagus gum #asparagus polysaccharide #TACE therapy

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Weng, Ling-Ling

소속기관 Department of Radiology, Shanghai Municipal Hospital of Traditional Chinese Medicine [TCM] Affiliate