Association of Methylation of the RAR-β Gene with Cigarette Smoking in Non-Small Cell Lung Cancer with Southern-central Chinese Population

Li, Wen; Deng, Jing; Wang, Shuang-Shuang; Ma, Liang; Pei, Jiang; Zeng, Xiao-Xi; Tang, Jian-Xin

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자료유형: 학술저널

저자정보: Li, Wen (Key Laboratory of Green Packaging and Application of Biological Nanotechnology of Hunan Province) Deng, Jing (College of Packaging and Material Engineering, Hunan University of Technology) Wang, Shuang-Shuang (Key Laboratory of Green Packaging and Application of Biological Nanotechnology of Hunan Province) Ma, Liang (Key Laboratory of Green Packaging and Application of Biological Nanotechnology of Hunan Province) Pei, Jiang (Key Laboratory of Green Packaging and Application of Biological Nanotechnology of Hunan Province) Zeng, Xiao-Xi (Key Laboratory of Green Packaging and Application of Biological Nanotechnology of Hunan Province) Tang, Jian-Xin (Key Laboratory of Green Packaging and Application of Biological Nanotechnology of Hunan Province)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제15권 제24호

발행연도: 2014.1

수록면: 10,937 - 10,941 (5page)

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Pathogenesis of lung cancer is a complicated biological process including multiple genetic and epigenetic changes. Since cigarette smoking is confirmed as the most main risk factor of non-small cell lung cancer (NSCLC), the aim of this study was to determine whether tobacco exposure plays a role in gene methylation. Methylation of the RAR-${\beta}$ gene were detected using methylation-specific polymerase chain reaction in DNA from 167 newly diagnosed cases with NSCLC and corresponding 105 controls. A significant statistical association was found in the detection rate of the promoter methylation of RAR-${\beta}$ gene between NSCLC and controls ($x^2$=166.01; p<0.01), and hypermethylation of the RAR-${\beta}$ gene was significantly associated with smoking status (p=0.038, p<0.05). No relationship was found between RAR-${\beta}$ gene methylation and pathologic staging including clinical stage, cell type, gender and drinking (p>0.05), and the methylation of RAR-${\beta}$ gene rate of NSCLC was slightly higher in stages III+IV (80.0%) than in I+II (70.8%). Similar results were obtained for methylation of the RAR-${\beta}$ gene between squamous cell carcinoma (77.9%) and other cell type lung cancer (73.9%). These results showed that the frequency of methylation increased gradually with the development of clinical stage in smoking-associated lung cancer patients, and tobacco smoke may be play a potential role in RAR-${\beta}$ gene methylation in the early pathogenesis and process in lung cancer, particularly squamous cell carcinoma. Aberrant promoter methylation is considered to be a promising marker of previous carcinogen exposure and cancer risk.

#Methylation #non-small cell lung cancer #$RAR{beta}$ gene #cigarette exposure

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Li, Wen

소속기관 Key Laboratory of Green Packaging and Application of Biological Nanotechnology, Hunan University of