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학술저널
저자정보
Zhou, Cheng-Jiang (School of Basic Medicine, Baotou Medical College) Zhang, Liu-Wei (Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center) Gao, Fang (School of Basic Medicine, Baotou Medical College) Zhang, Bin (School of Basic Medicine, Baotou Medical College) Wang, Ying (School of Basic Medicine, Baotou Medical College) Chen, Da-Fang (Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center) Jia, Yan-Bin (School of Basic Medicine, Baotou Medical College)
저널정보
아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제15권 제24호
발행연도
2014.1
수록면
10,719 - 10,722 (4page)

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Several lines of evidence suggest that MUC5AC genetic polymorphisms might confer susceptibility to H. pylori infection and therefore gastric cancer risk. We here assessed the association of common polymorphisms in the MUC5AC gene with H. pylori seroprevalence using an LD-based tagSNP approach in a north-western Chinese Han population. A total of 12 tagSNPs were successfully genotyped among 281 unrelated ethnic Han Chinese who had no cancer history, and no identifiable gastric disease or genetic disease. No significant association between any alleles, genotypes or haplotypes and H. pylori seroprevalence was observed. Our results suggest that common genetic variations in MUC5AC gene might not make a major contribution to the risk of H. pylori infection.

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