Survival Analysis of Oral Squamous Cell Carcinoma in a Subgroup of Young Patients

Fan, Yi; Zheng, Lei; Mao, Ming-Hui; Huang, Ming-Wei; Liu, Shu-Ming; Zhang, Jie; Li, Sheng-Lin; Zheng, Lei; Zhang, Jian-Guo

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자료유형: 학술저널

저자정보: Fan, Yi (Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology) Zheng, Lei (Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology) Mao, Ming-Hui (Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology) Huang, Ming-Wei (Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology) Liu, Shu-Ming (Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology) Zhang, Jie (Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology) Li, Sheng-Lin (Central Laboratory, Peking University School and Hospital of Stomatology) Zheng, Lei (Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology) Zhang, Jian-Guo (Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제15권 제20호

발행연도: 2014.1

수록면: 8,887 - 8,891 (5page)

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Oral squamous cell carcinoma (OSCC) is predominantly a disease of middle-aged men with long-term exposure to tobacco and alcohol. An increasing trend has been reported at a younger age worldwide. Clinical records of 100 patients under the age of 45 years treated specifically for oral cavity SCC in our hospital during a 10-year period were retrospectively analyzed to calculate the survival rates. An obvious male predominance coincided with smoking trend among Chinese young individuals and female patients were more likely to have no traditional risk factors such as smoking or drinking. The 5-year overall survival rate and disease-free survival rate were 61.0% and 75.5%, respectively, consistent with other published series over the decade showing a relatively better survival among the young. No significant differences clearly correlated with outcome when comparing non-smokers non-drinkers to ever-smokers and ever drinkers (P>0.05). Overall survival rate and disease free survival rate was found to be significantly higher in patients with early-stage disease than with advanced stage disease (P=0.001, P=0.009 respectively). The strong influence of clinical stage on prognosis emphasizes the importance of early diagnosis and treatment of oral malignancies for this unique clinical subgroup.

#Oral squamous cell carcinoma #oral cavity #survival #young patients #tobacco #alcohol

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Fan, Yi

소속기관 Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology