Malignant Transformation Rate and P53, and P16 Expression in Teratomatous Skin of Ovarian Mature Cystic Teratoma

Zhu, Hai-Li; Zou, Zhen-Ning; Lin, Pei-Xin; Li, Wen-Xia; Huang, Ye-En; Shi, Xiao-Xin; Shen, Hong

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자료유형: 학술저널

저자정보: Zhu, Hai-Li (Department of Pathology, Nanfang Hospital, Southern Medical University) Zou, Zhen-Ning (Department of Pathology, Nanfang Hospital, Southern Medical University) Lin, Pei-Xin (Department of Pathology, Nanfang Hospital, Southern Medical University) Li, Wen-Xia (Department of Pathology, Nanfang Hospital, Southern Medical University) Huang, Ye-En (Department of Pathology, Nanfang Hospital, Southern Medical University) Shi, Xiao-Xin (Department of Pathology, Nanfang Hospital, Southern Medical University) Shen, Hong (Department of Pathology, Nanfang Hospital, Southern Medical University)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제16권 제3호

발행연도: 2015.1

수록면: 1,165 - 1,168 (4page)

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Objective: To investigate the incidence of malignant transformation and P53 and P16 expression in teratomatous skin of ovarian mature cystic teratoma. Materials and Methods: Data on ovarian teratoma specimens in nearly 10 years were reviewed. P53 and P16 expression were detected by immunohistochemistry in 25 cases of teratomatous skin of ovarian mature cystic teratoma, 20 cases of squamous cell carcinoma and 2 cases of squamous cell carcinoma originated from teratomatous skin. Results: Of 1913 cases of ovarian mature cystic teratoma in nearly 10 years, only two cases of squamous cell carcinoma were found in teratomatous skin, with malignant transformation rate of 0.1045%. P53 expression was detected in 2 cases squamous cell carcinoma originated from teratomatous skin and P16 overexpression in one. There were no expressions of P53 and P16 in 25 cases of teratomatous skin of ovarian mature cystic teratoma. Of 20 cases of squamous cell carcinoma P53 overexpression (positive rate of 55%) was detected in 11 cases, P16 overexpression (positive rate of 35%) in 7 cases. The positive rates of P53 and P16 expression in squamous cell carcinomas were significantly higher than that in the teratomatous skins (p< 0.001, p= 0.002). Conclusions: There was low risk of malignant transformation in teratomatous skin of ovarian mature cystic teratoma which can be explained by lower P53 and P16 expressionin teratomas than that in squamous cell carcinoma.

#Teratoma-malignant transformation #p53-p16 #immunohistochemistry #squamous cell carcinoma

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