LCN2 Promoter Methylation Status as Novel Predictive Marker for Microvessel Density and Aggressive Tumor Phenotype in Breast Cancer Patients

Meka, Phanni bhushann; Jarjapu, Sarika; Nanchari, Santhoshi Rani; Vishwakarma, Sandeep Kumar; Edathara, Prajitha Mohandas; Gorre, Manjula; Cingeetham, Anuradha; Vuree, Sugunakar; Annamaneni, Sandhya; Dunna, Nageswara Rao; Mukta, Srinivasulu; Triveni, B; Satti, Vishnupriya

추천

검색

자료유형: 학술저널

저자정보: Meka, Phanni bhushann (Department of Genetics, Osmania University) Jarjapu, Sarika (Department of Genetics, Osmania University) Nanchari, Santhoshi Rani (Department of Genetics, Osmania University) Vishwakarma, Sandeep Kumar (Deccan College of Medical Sciences) Edathara, Prajitha Mohandas (Department of Genetics, Osmania University) Gorre, Manjula (Department of Genetics, Osmania University) Cingeetham, Anuradha (Department of Genetics, Osmania University) Vuree, Sugunakar (Department of Genetics, Osmania University) Annamaneni, Sandhya (Department of Genetics, Osmania University) Dunna, Nageswara Rao (School of Chemical & Biotechnology, Sastra University) Mukta, Srinivasulu (MNJ Institute of Oncology & Regional Cancer Centre) Triveni, B (MNJ Institute of Oncology & Regional Cancer Centre) Satti, Vishnupriya (Department of Genetics, Osmania University)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제16권 제12호

발행연도: 2015.1

수록면: 4,965 - 4,969 (5page)

이용수

📌

연구주제

📖

연구배경

🔬

연구방법

🏆

연구결과

초록· 키워드

오류제보하기

LCN2 (Lipocalin 2) is a 25 KD secreted acute phase protein, reported to be a novel regulator of angiogenesis in breast cancer. Up regulation of LCN2 had been observed in multiple cancers including breast cancer, pancreatic cancer and ovarian cancer. However, the role of LCN2 promoter methylation in the formation of microvessels is poorly understood. The aim of this study was to analyze the association of LCN 2 promoter methylation with microvessel formation and tumor cell proliferation in breast cancer patients. The LCN2 promoter methylation status was studied in 64 breast cancer tumors by methylation specific PCR (MSP). Evaluation of microvessel density (MVD) and Ki67 cell proliferation index was achieved by immunohistochemical staining using CD34 and MIB-1 antibodies, respectively. LCN2 promoter unmethylation status was observed in 43 (67.2%) of breast cancer patients whereas LCN2 methylation status was seen in 21 (32.8%). Further, LCN2 promoter unmethylation status was associated with aggressive tumor phenotype and elevated mean MVD in breast cancer patients.

#Lipocalin 2 #DNA methylation #microvessel density #cell proliferation #breast cancer

참고문헌 (0)

참고문헌 신청

참고문헌이 DBpia에서 서비스 중이라면, [참고문헌 신청]을 통해 등록해보세요

함께 읽어보면 좋을 논문

논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!