Association of Four ERCC1 and ERCC2 SNPs with Survival of Bone Tumour Patients

Hao, Ting; Feng, Wei; Zhang, Jie; Sun, Yong-Jian; Wang, Gang

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자료유형: 학술저널

저자정보: Hao, Ting (Department of Orthopedics, the Second Affiliated Hospital of Inner Mongolia Medical University) Feng, Wei (Department of Orthopedics, the Second Affiliated Hospital of Inner Mongolia Medical University) Zhang, Jie (Department of Endocrinology, the First Hospital of Huhhot) Sun, Yong-Jian (Department of Traumatic Orthopedics, Nanfang Hospital, Southern Medical University) Wang, Gang (Department of Traumatic Orthopedics, Nanfang Hospital, Southern Medical University)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제13권 제8호

발행연도: 2012.1

수록면: 3,821 - 3,824 (4page)

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Aim: SNPs of ERCC1 and ERCC2 genes have been found to be associated with response to platinum therapy in different clinical settings. In the current study, we investigated the relationship of SNPs in ERCC1 and ERCC2 to cisplain response and survival in osteosarcoma patients. Methods: 267 consecutive patients diagnosed with osteosarcoma between January 2003 to January 2005 were followed up until the end of January 2010. ERCC1 Asn118Asn, ERCC1 Gln504Lys, ERCC2 Asp312Asn and ERCC2 Lys751Gln polymorphisms were detected based upon the Sequenom MassARRAY platform.Results: For ERCC1 Asn118Asn, the variant genotype T/T was strongly significantly associated with a higher event free survival when compared with the wild-type C/C, with an adjusted OR (95% CI) of 0.39 (0.14-0.95). ERCC2 751 A/A genotype showed increased event free survival of osteosarcoma (HR=0.44; 95%CI=0.10-0.87). However, we did not find significant association of ERCC1 Gln504Lys and ERCC2 Asp312Asn polymorphisms with prognosis of osteosarcoma. Conclusions: We first report associations of four SNPs, ERCC1 Asn118Asn, ERCC1 Gln504Lys, ERCC2 Asp312Asn and ERCC2 Lys751Gln, with risk of death from osteosarcoma in a Chinese population, indicating ERCC1 118T/T and ERCC2 A/A may be used as surrogate markers for clinical outcome of osteosarcoma treatmetn with cisplain.

#ERCC1 #ERCC2 #polymorphisms #osteosarcoma #survival #cisplain treatment #China

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Hao, Ting

소속기관 Department of Orthopedics, the Second Affiliated Hospital of Inner Mongolia Medical University