Prognostic Significance of Annexin A1 Expression in Pancreatic Ductal Adenocarcinoma

Chen, Cong-Ying; Shen, Jia-Qing; Wang, Feng; Wan, Rong; Wang, Xing-Peng

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자료유형: 학술저널

저자정보: Chen, Cong-Ying (Department of Gastroenterology, Shanghai Tenth People's Hospital, Tongji University School of Medicine) Shen, Jia-Qing (Department of Gastroenterology, The First Affiliated Hospital of Soochow University) Wang, Feng (Department of Gastroenterology, Shanghai Tenth People's Hospital, Tongji University School of Medicine) Wan, Rong (Department of Gastroenterology, Shanghai Tenth People's Hospital, Tongji University School of Medicine) Wang, Xing-Peng (Department of Gastroenterology, Shanghai Tenth People's Hospital, Tongji University School of Medicine)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제13권 제9호

발행연도: 2012.1

수록면: 4,707 - 4,712 (6page)

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Annexin A1 is a 37-kDa calcium- and phospholipid-binding protein of the annexin superfamily considered to play an important role in tumorigenesis. However, associations with clinicopathological features in pancreatic ductal adenocarcinoma (PDAC) cases have yet to be fully defined. We therefore investigated the prognostic value of annexin A1 protein as a PDAC biomarker in 83 tumor and matched non-cancerous tissues or normal pancreas tissues. Expression was analyzed using real-time RT-PCR, Western blotting and immunohistochemistry. In non-tumor tissue, myoepithelial cells showed no or weak expression of annexin A1 while expression was strong and sometimes even located in the nuclei of endothelial cells in tumor tissue. High expression was significantly associated with advanced stage (P <0.05) and a worse overall survival (P <0.05). These results provide new insights to better understand the role of annexin A1 in PDAC survival, and might be relevant to prediction of prognosis and development of more effective therapeutic strategies aimed at improving survival.

#Annexin A1 #pancreatic ductal adenocarcinoma #prognosis

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Chen, Cong-Ying

소속기관 Department of Gastroenterology, Shanghai Tenth People's Hospital, Tongji University School of Medici