Hepatitis C Virus Prevalence and Genotyping among Hepatocellular Carcinoma Patients in Baghdad

Al-Kubaisy, Waqar Abd Al Qahar; Obaid, Kadhim Jawad; Noor, Nor Aini Mohd; Ibrahim, Nik Shamsidah Binti Nik; Al-Azawi, Ahmed Albu-Kareem

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저자정보: Al-Kubaisy, Waqar Abd Al Qahar (Faculty of Medicine, Universiti Teknologi MARA, Sungai Buloh Campus) Obaid, Kadhim Jawad (Faculty of Medicine, Universiti Teknologi MARA, Sungai Buloh Campus) Noor, Nor Aini Mohd (Faculty of Medicine, Universiti Teknologi MARA, Sungai Buloh Campus) Ibrahim, Nik Shamsidah Binti Nik (Faculty of Medicine, Universiti Teknologi MARA, Sungai Buloh Campus) Al-Azawi, Ahmed Albu-Kareem (University Hospital)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제15권 제18호

발행연도: 2014.1

수록면: 7,725 - 7,730 (6page)

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Hepatocellular carcinoma (HCC) is the third most common cause for cancer death in the world, now being especially linked to chronic hepatitis C virus (HCV) infection. This case-control study consisting of 65 HCC patients and 82 patients with other malignant tumours as controls was conducted to determine the association of HCV markers with HCC. Serum of each participant was obtained for detection of HCV Ab and RNA by DNA enzyme immunoassay (DEIA). Twenty six per cent (26.0%) of HCC patients had positive anti-HCV which was significantly greater than the control group (p=0.001). HCC patients significantly have a risk of exposure to HCV infection almost 3 times than the control group (OR=2.87, 95% C.I=1.1-7). Anti-HCV seropositive rate was significantly (p=0.03) higher among old age HCC patients and increases with age. Males with HCC significantly showed to have more than 9 times risk of exposure to HCV infection (OR=9.375, 95 % CI=1.299-67.647) than females. HCV-RNA seropositive rate was (70.8%) significantly higher among HCC patients compared to (22.2%) the control group (p=0.019). The most prevalent genotype (as a single or mixed pattern of infection) was HCV-1b. This study detected a significantly higher HCV seropositive rate of antibodies and RNA in HCC patients.

#Hepatocellular carcinoma #hepatitis C virus #HCV markers #Iraq

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