Interaction of Tobacco Smoking and Chewing with Angiotensin Converting Enzyme (Insertion/Deletion) Gene Polymorphisms and Risk of Lung Cancer in a High Risk Area from Northeast India

Phukan, Rup Kumar; Borah, Prasanta Kumar; Saikia, Bhaskar Jyoti; Das, Mandakini; Sekhon, Gaganpreet Singh; Mahanta, Jagadish

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저자정보: Phukan, Rup Kumar (Regional Medical Research Centre, N.E. Region [ICMR]) Borah, Prasanta Kumar (Regional Medical Research Centre, N.E. Region [ICMR]) Saikia, Bhaskar Jyoti (Regional Medical Research Centre, N.E. Region [ICMR]) Das, Mandakini (Regional Medical Research Centre, N.E. Region [ICMR]) Sekhon, Gaganpreet Singh (Regional Medical Research Centre, N.E. Region [ICMR]) Mahanta, Jagadish (Regional Medical Research Centre, N.E. Region [ICMR])

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제15권 제24호

발행연도: 2014.1

수록면: 10,691 - 10,695 (5page)

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Background: Association of angiotensin converting enzyme (ACE) gene polymorphisms with lung cancer susceptibility remains uncertain and varies with ethnicity. Northeast India represents a geographically, culturally, and ethnically isolated population. The area reports an especially high rate of tobacco usage in a variety of ways of consumption, compared with the rest of the Indian population. Materials and Methods: We conducted a population based case control study in two major high risk region for lung cancer from Northeast India. A total of 151 consecutive lung cancer cases diagnosed histopathologically and equal numbers of controls were recruited with record of relevant sociodemographic information. Blood samples were collected and processed to identify ACE gene polymorphism. Results: Significantly higher (40.4 % vs 29.1%, OR=1.97, CI=1.04-3.72; p=0.037) prevalence of the ACE II genotype was observed among lung cancer cases. Smoking was significantly associated with increased risk of lung cancer (OR=1.70, CI=1.02-2.81; p=0.041). An enhanced risk was also observed for interaction of ACE II genotype with tobacco smoking (OR=4.09, CI=1.51-11.05; p=0.005) and chewing (OR=3.68, CI=1.22-11.13; p=0.021). Conclusions: The present study indicates significant association s of the ACE II genotype with lung cancer in high risk Northeast India.

#Angiotensin converting enzyme #bradykinin #lung cancer #polymorphisms

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