Curcumin Analogue A501 induces G2/M Arrest and Apoptosis in Non-small Cell Lung Cancer Cells

Xia, Yi-Qun; Wei, Xiao-Yan; Li, Wu-Lan; Kanchana, Karvannan; Xu, Chao-Chao; Chen, Da-Hui; Chou, Pei-Hong; Jin, Rong; Wu, Jian-Zhang; Liang, Guang

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자료유형: 학술저널

저자정보: Xia, Yi-Qun (Chemical Biology Research Center, College of Pharmaceutical Sciences, Wenzhou Medical University) Wei, Xiao-Yan (Chemical Biology Research Center, College of Pharmaceutical Sciences, Wenzhou Medical University) Li, Wu-Lan (Chemical Biology Research Center, College of Pharmaceutical Sciences, Wenzhou Medical University) Kanchana, Karvannan (Chemical Biology Research Center, College of Pharmaceutical Sciences, Wenzhou Medical University) Xu, Chao-Chao (Chemical Biology Research Center, College of Pharmaceutical Sciences, Wenzhou Medical University) Chen, Da-Hui (Chemical Biology Research Center, College of Pharmaceutical Sciences, Wenzhou Medical University) Chou, Pei-Hong (Chemical Biology Research Center, College of Pharmaceutical Sciences, Wenzhou Medical University) Jin, Rong (Department of Digestive Diseases, The First Affiliated Hospital of Wenzhou Medical University) Wu, Jian-Zhang (Chemical Biology Research Center, College of Pharmaceutical Sciences, Wenzhou Medical University) Liang, Guang (Chemical Biology Research Center, College of Pharmaceutical Sciences, Wenzhou Medical University)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제15권 제16호

발행연도: 2014.1

수록면: 6,893 - 6,898 (6page)

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Curcumin and its analogues have been reported to exert anti-cancer activity against a variety of tumors. Here, we reported A501, a new curcumin analogue. The effect of A501 on cell viability was detected by MTT assay, the result showed that A501 had a better inhibiting effect on the four non-small cell lung cancer (NSCLC) cells than that of curcumin. Moreover, Colony forming experiment showed A501 significant restrained cell proliferation. Flow cytometry displayed A501 can cause G2/M arrest and induce apoptosis. Western blotting showed that A501 decreased the expression of cyclinB1, cdc-2, bcl-2, while increased the expression of p53, cleaved caspase-3 and bax. In conclusion, curcumin analogues A501 played antitumor activity by inhibiting cell proliferation and inducing apoptosis of NSCLC cells. And it was likely to be a promising starting point for the development of curcumin-based anticancer drugs.

#NSCLC #curcumin #antitumor #cycle arrest #apoptosis

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Xia, Yi-Qun

소속기관 Chemical Biology Research Center, College of Pharmaceutical Sciences, Wenzhou Medical University