Impact of Low Versus Conventional Doses of Chemotherapy During Transcatheter Arterial Chemo-embolization on Serum Fibrosis Indicators and Survival of Liver Cancer Patients

Kong, Wei-Dong; Cao, Jian-Ming; Xu, Jian; Chen, Bo; Yang, Tao; Xu, Tan-Tan; Lu, Guang-Ming; Li, Jun; Huang, Xin-En

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자료유형: 학술저널

저자정보: Kong, Wei-Dong (Department of Medical Imaging, Jinling Hospital, Clinical School of Medical College, Nanjing University) Cao, Jian-Ming (Department of Medical Imaging, Jinling Hospital, Clinical School of Medical College, Nanjing University) Xu, Jian (Department of Medical Imaging, Jinling Hospital, Clinical School of Medical College, Nanjing University) Chen, Bo (Department of Medical Imaging, Jinling Hospital, Clinical School of Medical College, Nanjing University) Yang, Tao (Department of Medical Imaging, Jinling Hospital, Clinical School of Medical College, Nanjing University) Xu, Tan-Tan (Department of Medical Imaging, Jinling Hospital, Clinical School of Medical College, Nanjing University) Lu, Guang-Ming (Department of Medical Imaging, Jinling Hospital, Clinical School of Medical College, Nanjing University) Li, Jun (Department of Oncology, Meishan Hospital Shanhai Meishan Co. Ltd.) Huang, Xin-En (Department of Chemotherapy, Jiangsu Cancer Hospital & Research Institute)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제13권 제9호

발행연도: 2012.1

수록면: 4,757 - 4,761 (5page)

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Objectives: To explore the impact of low- vs conventional-dose chemotherapy via transcatheter arterial chemo-embolization (TACE) on serum fibrosis indicators and treatment efficacy of hepatocellular cancer patients (HCC). Materials and Methods: Patients fulfilling the eligibility criteria were assigned to TACE in Group A (with low-dose chemotherapy) or Group B (conventional-dose chemotherapy). Four serum fibrosis related indicators, hyaluronic acid(HA), human pro-collagen type-III (hPC-III), laminin (LN), and collagen type-IV(IV-C) before TACE were compared with the values 7 days after TACE. The response rate and survival time were also compared between the two groups. Results: Fifty patients with HCC were enrolled in this study, including 25 in Group A and 25 in Group B. No significant differences were detected between the two groups in the four indicators before TACE. After TACE, the value of the four serum indicators increased significantly in Group B. However, no significant differences regarding these four indicators were found in Group A after TACE. Significant differences were demonstrated between the two groups after TACE, but median survival time and 1 or 2 year overall survival rates did not differ (P>0.05). Conclusions: Low-, compared with conventional-dose chemotherapy exerts the same impact on the variation of fibrosis related indicators and has no influence on median survival time and survival rate after TACE in HCC patients.

#Hepatocellular cancer #transcatheter arterial chemo-embolization #fibrosis indicators

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Kong, Wei-Dong

소속기관 Department of Medical Imaging, Jinling Hospital, Clinical School of Medical College, Nanjing Univers