Association of a p53 Codon 72 Gene Polymorphism with Environmental Factors and Risk of Lung Cancer: a Case Control Study in Mizoram and Manipur, a High Incidence Region in North East India

Saikia, Bhaskar Jyoti; Das, Mandakini; Sharma, Santanu Kumar; Sekhon, Gaganpreet Singh; Zomawia, Eric; Singh, Yanglem Mohen; Mahanta, Jagadish; Phukan, Rup Kumar

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자료유형: 학술저널

저자정보: Saikia, Bhaskar Jyoti (Regional Medical Research Centre, N.E. Region [ICMR]) Das, Mandakini (Regional Medical Research Centre, N.E. Region [ICMR]) Sharma, Santanu Kumar (Regional Medical Research Centre, N.E. Region [ICMR]) Sekhon, Gaganpreet Singh (Regional Medical Research Centre, N.E. Region [ICMR]) Zomawia, Eric (Civil Hospital) Singh, Yanglem Mohen (Regional Institute of Medical Sciences) Mahanta, Jagadish (Regional Medical Research Centre, N.E. Region [ICMR]) Phukan, Rup Kumar (Regional Medical Research Centre, N.E. Region [ICMR])

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제15권 제24호

발행연도: 2014.1

수록면: 10,653 - 10,658 (6page)

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Background: A very high incidence of lung cancer is observed in Mizoram and Manipur, North East India. We conducted a population based case control study to establish associations of p53 codon 72 polymorphisms and interactions with environmental factors for this high incidence. Material and Methods: A total of 272 lung cancer cases and 544 controls matched for age (${\pm}5years$), sex and ethnicity were collected and p53 codon 72 polymorphism genotypes were analyzed using a polymerase chain based restriction fragment length polymorphism assay. We used conditional multiple logistic regression analysis to calculate adjusted odds ratios and 95% confidence intervals after adjusting for confounding factors. Results: p53 Pro/Pro genotype was significantly associated with increased risk of lung cancer in the study population (adjusted OR=2.14, CI=1.35-3.38, p=0.001). Interactions of the p53 Pro/Pro genotype with exposure to wood smoke (adjusted OR=3.60, CI=1.85-6.98, p<0.001) and cooking oil fumes (adjusted OR=3.27, CI=1.55-6.87, p=0.002), betel quid chewing (adjusted OR=3.85, CI=1.96-7.55, p<0.001), tobacco smoking (adjusted OR=4.42, CI=2.27-8.63, p<0.001) and alcohol consumption (adjusted OR=3.31, CI=1.10-10.03, p=0.034) were significant regarding the increased risk of lung cancer in the study population. Conclusions: The present study provided preliminary evidence that a p53 codon 72 polymorphism may effect lung cancer risk in the study population, interacting synergistically with environmental factors.

#p53SNP #lung cancer #gene-environment interactions #North-East India

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