Virulence Genes of Helicobacter pylori in Gastritis, Peptic Ulcer and Gastric Cancer in Laos

Vannarath, Sengdao; Vilaichone, Ratha-Korn; Rasachak, Bouachanh; Mairiang, Pisaln; Yamaoka, Yoshio; Shiota, Seiji; Binh, Tran Thanh; Mahachai, Varocha

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자료유형: 학술저널

저자정보: Vannarath, Sengdao (Department of Gastroenterology, Mahosot Hospital) Vilaichone, Ratha-Korn (Gastroenterology Unit, Department of Medicine, Thammasat University Hospital) Rasachak, Bouachanh (Department of Gastroenterology, Mahosot Hospital) Mairiang, Pisaln (Department of Gastroenterology, Srinagarind Hospital, Khonkaen University) Yamaoka, Yoshio (Department of Medicine, Michael E. Debakey Veterans Affairs Medical Center and Baylor College of Medicine) Shiota, Seiji (Department of Environmental and Preventive Medicine, Oita University Faculty of Medicine) Binh, Tran Thanh (Department of Environmental and Preventive Medicine, Oita University Faculty of Medicine) Mahachai, Varocha (Division of Gastroenterology, Department of Medicine, Chulalongkorn University Hospital)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제15권 제20호

발행연도: 2014.1

수록면: 9,027 - 9,031 (5page)

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Background: Helicobacter pylori (H. pylori) infection is an established cause of peptic ulcers and gastric cancer. The aim of this study was to identify H. pylori genotypes and to examine their associations with geographical regions and gastritis, peptic ulcers and gastric cancer in Laos. Materials and Methods: A total of 329 Lao dyspeptic patients who underwent gastroscopy at Mahosot Hospital, Vientiane, Laos during December 2010 - March 2012 were enrolled. Two biopsy specimens (one each from the antrum and corpus) were obtained for CLO testing and only CLO test-positive gastric tissue were used to extract DNA. PCR and sequencing were identified for variants of the cagA and vacA genotypes. Results: Some 119 Laos patients (36.2%) were found to be infected with H. pylori including 83 with gastritis, 13 with gastric ulcers (GU), 20 with duodenal ulcers (DU) and 3 with gastric cancer. cagA was detected in 99.2%. East-Asian-type cagA (62%) and vacA s1c (64.7%) were predominant genotypes in Laos. vacA s1c-m1b was significantly higher in GU than gastritis (53.8% vs. 24.1%; P-value=0.04) whereas vacA s1a-m2 was significantly higher in DU than gastritis (40.0% vs. 16.9%; P-value=0.03). East-Asian-type cagA and vacA s1c were significantly higher in highland than lowland Lao (100% vs. 55.8%; P-value=0.001 and 88.2% vs. 61.5%, P-value=0.03 respectively). Conclusions: H. pylori is a common infection in Laos, as in other countries in Southeast Asia. The cagA gene was demonstrated in nearly all Laos patients, cagA and vacA genotypes being possible important factors in explaining H. pylori infection and disease outcomes in Laos.

#Helicobacter pylori #cagA gene #vacA gene #Laos

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