Genetic Variation in PSCA is Associated with Bladder Cancer Susceptibility in a Korean Population

Lee, Jun-Ho; Song, Hye-Rim; Kim, Hee Nam; Kweon, Sun-Seog; Yun, Yong-Woon; Choi, Jin-Su; Jung, Seung-Il; Kwon, Dong Deuk; Kim, Soo Hyun; Choi, Yoo-Duk; Shin, Min-Ho

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자료유형: 학술저널

저자정보: Lee, Jun-Ho (Department of Preventive Medicine, Chonnam National University Medical School) Song, Hye-Rim (Department of Laboratory Medicine, Chonnam National University Hwasun Hospital) Kim, Hee Nam (Center for Creative Biomedical Scientists, Chonnam National University) Kweon, Sun-Seog (Department of Preventive Medicine, Chonnam National University Medical School) Yun, Yong-Woon (Gwangju-Jeonnam Regional Cardiocerebrovascular Center, Chonnam National University Hospital) Choi, Jin-Su (Department of Preventive Medicine, Chonnam National University Medical School) Jung, Seung-Il (Department of Urology, Chonnam National University Medical School) Kwon, Dong Deuk (Department of Urology, Chonnam National University Medical School) Kim, Soo Hyun (Department of Laboratory Medicine, Chonnam National University Medical School) Choi, Yoo-Duk (Department of Pathology, Chonnam National University Medical School) Shin, Min-Ho (Department of Preventive Medicine, Chonnam National University Medical School)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제15권 제20호

발행연도: 2014.1

수록면: 8,901 - 8,904 (4page)

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Background: Genetic factors play important roles in the pathogenesis of human cancer. A recent genome wide association study (GWAS) identified an association between the rs2294008 polymorphism of the prostate stem cell antigen (PSCA) gene and bladder cancer risk in Caucasians. The aim of this study was to determine whether the rs2294008 polymorphism is similarly associated with bladder cancer susceptibility in a Korean population. Materials and Methods: We conducted a case-control study of 411 bladder cancer patients and 1,700 controls. Results: The frequencies of the CC, CT, and TT genotypes of the rs2294008 polymorphism were 16.9, 54.0, and 28.8% in bladder cancer patients and 24.4, 48.1, and 27.5% in controls, respectively. We found that the combined CT/TT genotypes were associated with a significantly increased risk of bladder cancer (OR CT/TT =1.58, 95% CI= 1.15-2.17), compared with the CC genotype. Smoking habits, tumor grade and tumor stage did not modify the association between rs2294008 and the risk of bladder cancer. Conclusions: Our study showed that the rs2294008 polymorphism in the PSCA gene is associated with the risk of bladder cancer in a Korean population, providing evidence that it may contribute to bladder carcinogenesis regardless of ethnicity.

#PSCA #bladder cancer #SNP #ethnicity

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