Evaluation of BCL-6, CD10, CD138 and MUM-1 Expression in Diffuse Large B-Cell Lymphoma patients: CD138 is a Marker of Poor Prognosis

Bodoor, Khaldon; Matalka, Ismail; Hayajneh, Rami; Haddad, Yazan; Gharaibeh, Waleed

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자료유형: 학술저널

저자정보: Bodoor, Khaldon (Department of Applied Biology, Faculty of Science and Arts, Jordan University of Science and Technology) Matalka, Ismail (Department of Pathology, Jordan University of Science and Technology) Hayajneh, Rami (Department of Applied Biology, Faculty of Science and Arts, Jordan University of Science and Technology) Haddad, Yazan (Department of Applied Biology, Faculty of Science and Arts, Jordan University of Science and Technology) Gharaibeh, Waleed (Department of Biology, University of Jordan)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제13권 제7호

발행연도: 2012.1

수록면: 3,037 - 3,046 (10page)

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The diffuse large B-cell lymphoma (DLBCL) encompasses two major groups of tumors with uneven survival outcomes - germinal center B-cell (GCB) and non-germinal center B-cell (non-GCB). In the present study, we investigated the expression of GCB markers (BCL-6 and CD10) and non-GCB markers (CD138 and MUM-1) in an effort to evaluate their prognostic value. Paraffin-embedded tumor biopsies of 46 Jordanian DLBCL patients were analyzed, retrospectively, by immunohistochemistry to investigate the expression of BCL-6, CD10, CD138 and MUM-1. In addition, survival curves were calculated with reference to marker expression, age, sex and nodal involvement. Positive expression of BCL-6, CD10, CD138 and MUM-1 was shown in 78%, 61%, 39% and 91% of the cases, respectively, that of BCL-6 being associated with better overall survival (p = 0.02), whereas positive CD138 was linked with poor overall survival (p = 0.01). The expression of CD10 and MUM-1 had no impact on the overall survival. Among the clinical characteristics studied, diagnosis at an early age, nodal involvement and maleness were associated with a higher overall survival for DLBCL patients. Our results underline the importance of BCL-6 as a marker of better prognosis and CD138 as a marker of poor prognosis for DLBCL patients.

#Diffuse large B-cell lymphoma #immunohistochemistry #BCL 6 #CD10 #CD138 #MUM 1 #prognosis

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