Concurrent Chemoradiotherapy Versus Radiotherapy Alone for Locoregionally Advanced Nasopharyngeal Carcinoma

Yu, Hong-Sheng; Wang, Xin; Song, Ai-Qin; Liu, Ning; Zhang, Wei; Yu, Li

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자료유형: 학술저널

저자정보: Yu, Hong-Sheng (Department of Oncology, the Affiliated Hospital of Medical College, Qingdao University) Wang, Xin (Department of Otorhinolaryngology-Head and Neck Surgery, The First Hospital of Jilin University) Song, Ai-Qin (Department of Oncology, the Affiliated Hospital of Medical College, Qingdao University) Liu, Ning (Department of Oncology, the Affiliated Hospital of Medical College, Qingdao University) Zhang, Wei (Department of Oncology, the Affiliated Hospital of Medical College, Qingdao University) Yu, Li (Department of Oncology, the Affiliated Hospital of Medical College, Qingdao University)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제13권 제8호

발행연도: 2012.1

수록면: 3,961 - 3,965 (5page)

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Objective: To compare the clinical effects of concurrent radiochemotherapy with those of radiotherapy in treating locally advanced nasopharyngeal carcinoma (Stage III~IVa). Methods: A total of 95 patients suffering from nasopharyngeal carcinoma (Stage III~IVa) were divided into two groups: concurrent radiochemotherapy (Group CCRT, n=49) and radiotherapy (Group RT, n=46). The two groups were both delivered conventional fractionated radiotherapy, while Group CCRT also received three cycles of PF (DDP+5-Fu) or PLF (DDP+5-Fu+CF) chemotherapy. Results: The complete remission rate and total remission rate of Group CCRT were higher than those of Group RT ($X^2$=4.72~7.19, P<0.05). The one-year overall survival (OS) rate calculated by the life table method, was also higher than that of Group RT ($X^2$=4.24, P<0.05) as well as the 3-year OS rate, nasopharyngeal control rate and cervical lymph nodes' control rate ($X^2$=4.28~4.40, P<0.05). In addition, the 5-year OS and metastasis-free rates of Group CCRT were higher than those of Group RT and the differences were of statistical importance ($X^2$=3.96~8.26, P<0.05). However, acute toxicity was also obviously higher, the difference in gastrointestinal reactions being statistically significant ($X^2$=11.70, P<0.05). Conclusion: This study demonstrated that concurrent radiochemotherapy could improve the remission rate, overall survival rate and locally control rate. The toxicity of concurrent radiochemotherapy could be tolerated by the patients.

#Nasopharyngeal carcinoma #radiotherapy #chemotherapy #remission rate #survival rate #toxicity

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