Red Cell Distribution Width as a Predictor of Prostate Cancer Progression

Albayrak, Sebahattin; Zengin, Kursad; Tanik, Serhat; Bakirtas, Hasan; Imamoglu, Abdurrahim; Gurdal, Mesut

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자료유형: 학술저널

저자정보: Albayrak, Sebahattin (Department of Urology, School of Medicine, Bozok University) Zengin, Kursad (Department of Urology, School of Medicine, Bozok University) Tanik, Serhat (Department of Urology, School of Medicine, Bozok University) Bakirtas, Hasan (Department of Urology, School of Medicine, Bozok University) Imamoglu, Abdurrahim (Department of Urology, School of Medicine, Bozok University) Gurdal, Mesut (Department of Urology, School of Medicine, Bozok University)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제15권 제18호

발행연도: 2014.1

수록면: 7,781 - 7,784 (4page)

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Background: The aims of this study were to investigate the utility of red blood cell distribution width (RDW) as a simple and readily available marker in prostate cancer, as well as to evaluate RDW as a predictor of progression in prostate cancer patients. Materials and Methods: We evaluated 62 newly diagnosed prostate cancer patients who underwent transrectal ultrasound (TRUS)-guided biopsy and 62 healthy controls of mean age 64 (range, 45-75) years at the Urology Clinic of Bozok University Hospital. Data collection was performed using our laboratory information system database to retrieve findings regarding RDW, hemoglobin, prostatespecific antigen (PSA), and age. The RDW values were compared between the healthy control group and prostate cancer patients. A high risk of progression as defined as a Gleason score (GS) >6, total number of cores positive for cancer >33%, each core containing >50% cancer cells, and a prostate-specific antigen (PSA) level >10 ng/mL. Patients were classified according to risk of progression, as well as divided into subgroups according to the RDW quartile. Results: The mean RDW value of prostate cancer patients was 14.6, compared with 13.7 in the healthy control group (p=0.001). A higher RDW was associated with an increased risk of progression, whereas a lower RDW value was correlated with a low risk of progression. Conclusions: RDW is an easily derived measure that might, in combination with other markers, help predict prostate cancer risk and progression. We suggest that RDW may be used in combination with other parameters in the assessment of prostate cancer.

#Prostate cancer #progression #red blood cell distribution width

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