High Monocarboxylate Transporter 4 Protein Expression in Stromal Cells Predicts Adverse Survival in Gastric Cancer

Yan, Ping; Li, Yu-Hong; Tang, Zhi-Jiao; Shu, Xiang; Liu, Xia

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저자정보: Yan, Ping (Department of Occupational and Environmental Health, School of Public Health, Wuhan University) Li, Yu-Hong (Department of Pathology, Medical College, Wuhan University of Science and Technology) Tang, Zhi-Jiao (Department of Pathology, Wuhan Health and Medical Technology Co., Ltd.) Shu, Xiang (Department of Pathology, Wuhan Health and Medical Technology Co., Ltd.) Liu, Xia (Department of Pathology, Wuhan Health and Medical Technology Co., Ltd.)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제15권 제20호

발행연도: 2014.1

수록면: 8,923 - 8,929 (7page)

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Background: Increasing evidence suggests that stromal monocarboxylate transporter 4 (MCT4) and carbonic anhydrase IX (CA IX) may play key roles in tumor development. However, their clinical value remains largely unexplored in gastric cancer (GC). The present study aimed to determine clinicopathological significance and prognostic values of stromal MCT4 and CA IX in GC. Materials and Methods: Specimens from 143 GC patients were immunohistochemically stained using polyclonal anti-MCT4 and anti-CA IX antibodies. Expression was correlated with patient clinicopathologic characteristics and survival data. Results: High stromal MCT4 expression was detected in 72 of 143 (50.3%) GCs and high CA IX in 74 (51.7%). Both high stromal MCT4 and CA IX were correlated with advanced TNM stage (p=0.000; p=0.000). High CA IX expression was positively related to depth of invasion (p=0.022) and positive lymph nodes (p=0.002) as well. Survival analysis indicated high expression of stromal MCT4 to be an independent factor in predicting poor overall survival (OS) (HR and 95%CI=1.962, 1.032-3.729, p=0.040) and disease free survival (DFS) (HR and 95%CI=2.081, 1.158-3.741, p=0.014) of GC patients. However, high CA IX expression exhibited no significant predictive value. Conclusions: These findings suggest that high expression of stromal MCT4 and CA IX proteins is significantly correlated with GC progression. High stromal MCT4 heralds worse outcome of GC patient, suggesting a novel candidate prognostic marker and therapeutic target.

#Monocarboxylate transporter 4 #carbonic anhydrase IX #gastric cancer #survival #prognosis

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Yan, Ping

소속기관 Department of Occupational and Environmental Health, School of Public Health, Wuhan University