Evaluation of Endoscopic Characteristics of Upper Gastrointestinal Polyps in Patients with Familial Adenomatous Polyposis

Fatemi, Seyed Reza; Safaee, Azadeh; Pasha, Sara; Pourhoseingholi, Mohamad Amin; Bahrainei, Rasool; Molaei, Mahsa

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저자정보: Fatemi, Seyed Reza (Gastroenterology and Liver Diseases Research Center, Shahid Beheshti University of Medical Sciences) Safaee, Azadeh (Gastroenterology and Liver Diseases Research Center, Shahid Beheshti University of Medical Sciences) Pasha, Sara (Gastroenterology and Liver Diseases Research Center, Shahid Beheshti University of Medical Sciences) Pourhoseingholi, Mohamad Amin (Gastroenterology and Liver Diseases Research Center, Shahid Beheshti University of Medical Sciences) Bahrainei, Rasool (Gastroenterology and Liver Diseases Research Center, Shahid Beheshti University of Medical Sciences) Molaei, Mahsa (Gastroenterology and Liver Diseases Research Center, Shahid Beheshti University of Medical Sciences)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제15권 제16호

발행연도: 2014.1

수록면: 6,945 - 6,948 (4page)

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Background: Familial adenomatous polyposis (FAP) is a disease inherited in an autosomal dominant fashion. Most FAP patients develop upper gastrointestinal polyps; especially those in the antrum and duodenum are usually neoplastic. The aim of this study was to evaluate the prevalence of gastroduodenal polyps in Iranian FAP patients. Materials and Methods: 28 patients affected by FAP underwent front-view and side-view endoscopy. Papillary biopsies were performed in all patients. Location of polyps, their number and size, pathology study, patient general information (gender, age, family history of FAP or colorectal cancer and gastroduodenal polyps) were analyzed. Results: Gastric polyps were seen in 39.3 % of patients. Some 72.7% of the affected individuals had fundic gland polyps and 36.36% had hyperplastic polyps. Duodenal adenoma was observed in 25% of patients. While 57% of patients had tubular adenoma with low grade dysplasia, 42.8% showed tubulovillous adenoma with low grade dysplasia. Conclusions: Findings of this study indicated that the prevalence of gastroduodenal polyps in FAP patients is high and dysplasia may be evident in duodenal polyps. Therefore, it appears that routine gastroduodenal endoscopy in FAP patients is necessary.

#Gastric polyp #duodenal adenoma #familial adenomatous polyposis #spigelman stage

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Fatemi, Seyed Reza

소속기관 Gastroenterology and Liver Diseases Research Center, Shahid Beheshti University of Medical Sciences