Clinicopathological Features in Bilateral Breast Cancer

Baykara, Meltem; Ozturk, Selcuk Cemil; Buyukberber, Suleyman; Helvaci, Kaan; Ozdemir, Nuriye; Alkis, Necati; Berk, Veli; Koca, Dogan; Coskun, Ugur; Oksuzoglu, Berna; Uncu, Dogan; Arpaci, Erkan; Ustaalioglu, Basak Oven; Demirci, Umut; Kucukoner, Mehmet; Dogu, Gamze Gokoz; Alici, Suleyman; Akman, Tulay; Ozkan, Metin; Aslan, Ulku Yalcintas; Durnali, Ayse Gok; Benekli, Mustafa

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자료유형: 학술저널

저자정보: Baykara, Meltem (Department of Medical Oncology, Gazi University Medical Faculty) Ozturk, Selcuk Cemil (Department of Medical Oncology, Gazi University Medical Faculty) Buyukberber, Suleyman (Department of Medical Oncology, Gazi University Medical Faculty) Helvaci, Kaan (Department of Medical Oncology, Gazi University Medical Faculty) Ozdemir, Nuriye (Department of Medical Oncology, Gazi University Medical Faculty) Alkis, Necati (Department of Medical Oncology, Gazi University Medical Faculty) Berk, Veli (Department of Medical Oncology, Gazi University Medical Faculty) Koca, Dogan (Department of Medical Oncology, Gazi University Medical Faculty) Coskun, Ugur (Department of Medical Oncology, Gazi University Medical Faculty) Oksuzoglu, Berna (Department of Medical Oncology, Gazi University Medical Faculty) Uncu, Dogan (Department of Medical Oncology, Gazi University Medical Faculty) Arpaci, Erkan (Department of Medical Oncology, Gazi University Medical Faculty) Ustaalioglu, Basak Oven (Department of Medical Oncology, Gazi University Medical Faculty) Demirci, Umut (Department of Medical Oncology, Gazi University Medical Faculty) Kucukoner, Mehmet (Department of Medical Oncology, Gazi University Medical Faculty) Dogu, Gamze Gokoz (Department) Alici, Suleyman Akman, Tulay Ozkan, Metin Aslan, Ulku Yalcintas Durnali, Ayse Gok Benekli, Mustafa

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제13권 제9호

발행연도: 2012.1

수록면: 4,571 - 4,575 (5page)

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Introduction and Purpose: The frequency of bilateral breast cancer is 1.4-11.0% among all breast cancers. It can present as synchronous (SC) or metachronous (MC). Data regarding clinical course of bilateral breast cancer are scarce. In this study, we therefore evaluated demographic, pathological and clinical characteristics, treatments and responses in bilateral breast cancer cases; making distinctions between metachronous-synchronous and comparing with historic one-sided data for the same parameters. Materials and Methods: One hundred fifty bilateral breast cancer cases from ten different centers between 2000 and 2011 were retrospectively scanned. Age of the cases, family history, menopausal status, pathological features, pathological stages, neoadjuvant, surgery, adjuvant and palliative chemotherapy/radiotherapy were examined in the context of the first and second occurrence and discussed with reference to the literature. Results: Metachronous and synchronous groups showed similar age, menopausal status, tumor type, HER2/neu expression; the family history tumor grade, tumor stage, ER-negativity rate, local and distant metastases rates, surgery, adjuvant chemotherapy application rates were identified as significantly different. Palliative chemotherapy response rate was greater in the metachronous group but median PFS rates did not differ between the groups. Conclusion: Although bilateral breast cancer is not frequent, MC breast cancer is different from SC breast cancer by having more advanced grade, stage, less ER expression, more frequent rates of local relapse and distant metastasis and better response to chemotherapy in case of relapse/metastasis.

#Bilateral breast cancer #synchronous #metachronous #clinicopathological characteristics #Turkey

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