Association between Ras association domain family 1A Promoter Methylation and Esophageal Squamous Cell Carcinoma: a Meta-analysis

Yang, Jian-Zhou; Ji, Ai-Fang; Wang, Jin-Sheng; Chen, Zhong-Yi; Wen, Shi Wu

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자료유형: 학술저널

저자정보: Yang, Jian-Zhou (School of Public Health, Central South University) Ji, Ai-Fang (Central Laboratory, Heping Hospital Affiliated to Changzhi Medical College) Wang, Jin-Sheng (Central Laboratory, Heping Hospital Affiliated to Changzhi Medical College) Chen, Zhong-Yi (Central Laboratory, Heping Hospital Affiliated to Changzhi Medical College) Wen, Shi Wu (School of Public Health, Central South University)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제15권 제9호

발행연도: 2014.1

수록면: 3,921 - 3,925 (5page)

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RASSF1A has been reported to be a candidate tumor suppressor in esophageal squamous cell carcinoma (ESCC). However, the association between RASSF1A promoter methylation and ESCC remains unclear. Eligible studies were identified through searching PubMed, Medline, Web of Science, and the China National Knowledge Infrastucture database. Studies were pooled and odds ratios (ORs) with corresponding confidence intervals (CIs) were calculated. Funnel plots were also performed to evaluate publication bias. Twelve studies involving 859 cases and 675 controls were included in this meta-analysis. A significant association was observed between RASSF1A methylation and ESCC overall (OR = 11.7, 95% CI: 6.59-20.9, z=8.36, P<0.00001). Subgroup analysis showed that the OR for heterogeneous tissues was 5.35 (95% CI = 2.95-9.71) while for autologous tissues it was 16.0 (8.31-30.96). For patient sample size, the OR for the <50 subgroup was 9.92 (95% CI = 2.88-34.2) and for the 50 case group was 13.1 (95% CI = 6.59-25.91). The OR for a relationship between RASSF1A methylation and TNM stages was 0.27 (95% CI=0.10-0.77), whereas there were no significant differences in RASSF1A methylation in relation to gender and differentiation among ESCC cases. This meta-analysis suggests a significant association between RASSF1A methylation and ESCC.

#RAS associations domain family 1A #methylation #esophageal squamous cell carcinoma #meta-analysis

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