High Serum Level of Retinol and α-Tocopherol Affords Protection Against Oral Cancer in a Multiethnic Population

Athirajan, Vimmitra; Razak, Ishak Abdul; Thurairajah, Nalina; Ghani, Wan Maria Nabillah; Ching, Helen-Ng Lee; Yang, Yi-Hsin; Peng, Karen-Ng Lee; Rahman, Zainal Ariff Abdul; Mustafa, Wan Mahadzir Wan; Abraham, Mannil Thomas; Kiong, Tay Keng; Mun, Yuen Kar; Jalil, Norma; Zain, Rosnah Binti

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저자정보: Athirajan, Vimmitra (Oral Cancer Research & Coordinating Centre, Faculty of Dentistry, University Malaya) Razak, Ishak Abdul (Oral Cancer Research & Coordinating Centre, Faculty of Dentistry, University Malaya) Thurairajah, Nalina (Centre of Pre-U Studies, UCSI University) Ghani, Wan Maria Nabillah (Oral Cancer Research & Coordinating Centre, Faculty of Dentistry, University Malaya) Ching, Helen-Ng Lee (Oral Cancer Research & Coordinating Centre, Faculty of Dentistry, University Malaya) Yang, Yi-Hsin (Department of Dental Hygiene, College of Dental Medicine, Kaohsiung Medical University) Peng, Karen-Ng Lee (Oral Cancer Research & Coordinating Centre, Faculty of Dentistry, University Malaya) Rahman, Zainal Ariff Abdul (Department of Oral-Maxillofacial Surgical and Medical Sciences, Faculty of Dentistry, University Malaya) Mustafa, Wan Mahadzir Wan (Oral Health Division, Ministry of Health Malaysia) Abraham, Mannil Thomas (Oral Health Division, Ministry of Health Malaysia) Kiong, Tay Keng (Oral Health Division, Ministry of Health Malaysia) Mun, Yuen Kar (Oral Health Division, Ministry of Health Malaysia) Jalil, Norma (Oral Health Division, Ministry of Health Malaysia) Zain, Rosnah Binti (Oral Cancer Research & Coordinating Centre, Faculty of Dentistry, Univer)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제15권 제19호

발행연도: 2014.1

수록면: 8,183 - 8,189 (7page)

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Background: A comparative cross-sectional study involving oral cancer patients and healthy individuals was designed to investigate associations between retinol, ${\alpha}$-tocopherol and ${\beta}$-carotene with the risk of oral cancer. Materials and Methods: This study included a total of 240 matched cases and controls where subjects were selected from the Malaysian Oral Cancer Database and Tissue Bank System (MOCDTBS). Retinol, ${\alpha}$-tocopherol and ${\beta}$-carotene levels and intake were examined by high-performance liquid chromatography (HPLC) and food frequency questionnaire (FFQ) respectively. Results: It was found that results from the two methods applied did not correlate, so that further analysis was done using the HPLC method utilising blood serum. Serum levels of retinol and ${\alpha}$-tocopherol among cases ($0.177{\pm}0.081$, $1.649{\pm}1.670{\mu}g/ml$) were significantly lower than in controls ($0.264{\pm}0.137$, $3.225{\pm}2.054{\mu}g/ml$) (p<0.005). Although serum level of ${\beta}$-carotene among cases ($0.106{\pm}0.159{\mu}g/ml$) were lower compared to controls ($0.134{\pm}0.131{\mu}g/ml$), statistical significance was not observed. Logistic regression analysis showed that high serum level of retinol (OR=0.501, 95% CI=0.254-0.992, p<0.05) and ${\alpha}$-tocopherol (OR=0.184, 95% CI=0.091-0.370, p<0.05) was significantly related to lower risk of oral cancer, whereas no relationship was observed between ${\beta}$-carotene and oral cancer risk. Conclusions: High serum levels of retinol and ${\alpha}$-tocopherol confer protection against oral cancer risk.

#Oral cancer #micronutrients #retinol #${alpha}$-tocopherol #${beta}$-carotene #Malaysia

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