Clinical Study on Carboplatin for Treating Pediatric Patients with Wilms Tumors

Zhang, Yong; Sun, Ling-Li; Li, Tao; Sun, Hui; Mao, Guo-Jia

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저자정보: Zhang, Yong (Shiyan Taihe Hospital of Hubei Province Department of Pediatrics, The Affiliated Hospital of Hubei Medical College) Sun, Ling-Li (Shiyan Taihe Hospital of Hubei Province Department of Pediatrics, The Affiliated Hospital of Hubei Medical College) Li, Tao (Shiyan Taihe Hospital of Hubei Province Department of Pediatrics, The Affiliated Hospital of Hubei Medical College) Sun, Hui (Shiyan Taihe Hospital of Hubei Province Department of Pediatrics, The Affiliated Hospital of Hubei Medical College) Mao, Guo-Jia (Department of Surgery, Jiujiang Third People's Hospital of Jiangxi Province)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제15권 제17호

발행연도: 2014.1

수록면: 7,277 - 7,280 (4page)

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This analysis was conducted to evaluate the efficacy and safety of carboplatin based chemotherapy in treating pediatric patients with Wilms tumors. Methods: Clinical studies evaluating the efficacy and safety of carboplatin based regimens on response and safety for pediatric patients with Wilms tumors were identified using a predefined search strategy. Pooled response rates (RRs) of treatment were calculated. Results: In carboplatin based regimens, 4 clinical studies which including 127 patients with advanced Wilms tumors were considered eligible for inclusion. With this carboplatin based chemotherapy, 2 clinical studies included carboplatin, ifosfamide and etoposide. Systemic analysis suggested that, in all patients, the pooled PR was 64.5% (82/127) in carboplatin based regimens. Thrombocytopenia and leukocytopenia were the main side effects. No grade III or IV renal or liver toxicity was observed. No treatment related death occurred with carboplatin based treatment. Conclusion: This systemic analysis suggests that carboplatine based regimens are associated with a reasonable response rate and accepted toxicities for treating pediatric patients with Wilms tumors.

#Carboplatine #Wilms tumor #toxicity

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Zhang, Yong

소속기관 Shiyan Taihe Hospital of Hubei Province Department of Pediatrics, The Affiliated Hospital of Hubei M