Tanshinone II-A Inhibits Angiogenesis through Down Regulation of COX-2 in Human Colorectal Cancer

Zhou, Li-Hong; Hu, Qiang; Sui, Hua; Ci, Shu-Jun; Wang, Yan; Liu, Xuan; Liu, Ning-Ning; Yin, Pei-Hao; Qin, Jian-Min; Li, Qi

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저자정보: Zhou, Li-Hong (Clinic Oncology, Putuo Hospital & Cancer Institute, Shanghai University of Traditional Chinese Medicine) Hu, Qiang (Department of Genernal Surgery, Dahua Hospital) Sui, Hua (Clinic Oncology, Putuo Hospital & Cancer Institute, Shanghai University of Traditional Chinese Medicine) Ci, Shu-Jun (Clinic Oncology, Putuo Hospital & Cancer Institute, Shanghai University of Traditional Chinese Medicine) Wang, Yan (Clinic Oncology, Putuo Hospital & Cancer Institute, Shanghai University of Traditional Chinese Medicine) Liu, Xuan (Clinic Oncology, Putuo Hospital & Cancer Institute, Shanghai University of Traditional Chinese Medicine) Liu, Ning-Ning (Clinic Oncology, Putuo Hospital & Cancer Institute, Shanghai University of Traditional Chinese Medicine) Yin, Pei-Hao (Department of Genernal Surgery, Putuo Hospital, Shanghai University of Traditional Chinese Medicine) Qin, Jian-Min (Department of Genernal Surgery, Putuo Hospital, Shanghai University of Traditional Chinese Medicine) Li, Qi (Clinic Oncology, Putuo Hospital & Cancer Institute, Shanghai University of Traditional Chinese Medicine)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제13권 제9호

발행연도: 2012.1

수록면: 4,453 - 4,458 (6page)

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Angiogenesis plays a significant role in colorectal cancer (CRC) and cyclooxygenase-2 (COX-2) appears to be involved with multiple aspects of CRC angiogenesis. Our aim was to investigate the inhibitory effects of Tan II-A (Tanshinone II-A, Tan II-A) on tumor growth in mice, as well as alteration of expression of COX-2 and VEGF in CRC. We established the mice xenograft model of C26 CRC cell line, and injected 0.5, 1, 2mg/kg of Tan II-A and 1mg/kg of 5-FU in respectively in vivo. Then, we assayed tumor weight and volume, and evaluated microvascular density and expression of VEGF. COX-2 promoter and COX-2 plasmids were transfected into HCT-116 cells, followed by detection of COX-2 promoter activity by chemiluminescence, and detection of COX-2 mRNA expression by fluorescence quantitative PCR. Taken together, the results showed Tan II-A could inhibit tumor growth and suppress the VEGF level in vivo. HCT-116 cell experiments showed marked inhibitory effects of Tan II-A on COX-2 and VEGF in a dose-dependent manner. The results indicate that Tan II-A can effectively inhibit tumor growth and angiogenesis of human colorectal cancer via inhibiting the expression level of COX-2 and VEGF.

#Tanshinone II-A #colorectal carcinoma #angiogenesis #cyclooxygenase 2 #vascular endothelial growth factor

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Zhou, Li-Hong

소속기관 Clinic Oncology, Putuo Hospital & Cancer Institute, Shanghai University of Traditional Chinese M