Treatment Interruption During Concurrent Chemoradiotherapy of Uterine Cervical Cancer; Analysis of Factors and Outcomes

Krusun, Srichai; Pesee, Montien; Supakalin, Narudom; Thamronganantasakul, Komsan; Supaadirek, Chunsri; Padoongcharoen, Prawat

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자료유형: 학술저널

저자정보: Krusun, Srichai (Department of Radiology, Faculty of Medicine, Khon Kaen University) Pesee, Montien (Department of Radiology, Faculty of Medicine, Khon Kaen University) Supakalin, Narudom (Department of Radiology, Faculty of Medicine, Khon Kaen University) Thamronganantasakul, Komsan (Department of Radiology, Faculty of Medicine, Khon Kaen University) Supaadirek, Chunsri (Department of Radiology, Faculty of Medicine, Khon Kaen University) Padoongcharoen, Prawat (Department of Radiology, Faculty of Medicine, Khon Kaen University)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제15권 제14호

발행연도: 2014.1

수록면: 5,653 - 5,657 (5page)

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Background: To evaluate factors which effect treatment interruption during concurrent chemoradiotherapy (CCRT) and overall survival in patients with uterine cervical cancer stage IB2-IVA in Srinagarind Hospital. Materials and Methods: Between January 2006 and December 2007, 107 patients with stage IB2-IVA as FIGO staging, 2000, were treated with CCRT in Srinagarind Hospital. Factors which caused treatment interruptions and impacted on overall survival were reviewed and analyzed. Results: Twenty of 107 patients had treatment interruption during CCRT in patients with uterine cervical cancer stage IB2-IVA in Srinagarind Hospital. The causes of treatment interruption were as follows: hematologic toxicity was found in 16 of 20 cases, 12 cases with grade 2 and 4 cases with grade 3; three of 20 cases had gastrointestinal toxicities, 1 case with grade 2 and 2 cases with grade 3; one case had grade 3 skin toxicity. The mean total treatment time of the uninterrupted and interrupted groups were significantly different (78.98 days vs 161.80 days, p <0.001). The patients who could tolerate ${\geq}5$ cycles of cisplatin administration had significantly higher mean white blood counts (WBC) ($9,769cells/mm^3$ vs $7,141cells/mm^3$, p=0.02). The mean initial hemoglobin (Hb) in the uninterrupted group was significantly higher than the interrupted group (11.5 mg% vs 10.3 mg%, p=0.03). Other factors including age, KPS, initial platelets, initial serum creatinine levels showed no statistical significance. The 3-year overall survival of the uninterrupted group was better than in the interrupted group (78.6% vs 55.0%, p=0.03). Conclusions: The initial Hb and WBC levels were significantly correlated with treatment interruption during CCRT in patients with uterine cervical cancer. The 3-year overall survival of the uninterrupted group was significantly better than interrupted group. These factors may then be used indirectly to predict the outcomes of treatment.

#Treatment interruption #uterine cervical cancer #concurrent chemoradiotherapy #factors #outcomes

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Krusun, Srichai

소속기관 Division of Radiotherapy, Department of Radiology, Srinagarind Hospital, Faculty of Medicine, Khon K