Interaction of XRCC1 and XPD Gene Polymorphisms with Lifestyle and Environmental Factors Regarding Susceptibility to Lung Cancer in a High Incidence Population in North East India

Saikia, Bhaskar Jyoti; Phukan, Rup Kumar; Sharma, Santanu Kumar; Sekhon, Gaganpreet Singh; Mahanta, Jagadish

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자료유형: 학술저널

저자정보: Saikia, Bhaskar Jyoti (Regional Medical Research Centre, N.E. Region [ICMR]) Phukan, Rup Kumar (Regional Medical Research Centre, N.E. Region [ICMR]) Sharma, Santanu Kumar (Regional Medical Research Centre, N.E. Region [ICMR]) Sekhon, Gaganpreet Singh (Regional Medical Research Centre, N.E. Region [ICMR]) Mahanta, Jagadish (Regional Medical Research Centre, N.E. Region [ICMR])

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제15권 제5호

발행연도: 2014.1

수록면: 1,993 - 1,999 (7page)

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Background: This study aimed to explore the role of XRCC1 (Arg399Gln) and XPD (Lys751Gln) gene polymorphisms, lifestyle and environmental factors as well as their possible interactions in propensity to develop lung cancer in a population with high incidence from North East India. Materials and Methods: A total of 272 lung cancer cases and 544 controls were collected and XRCC1 (Arg399Gln) and XPD (Lys751Gln) genotypes were analyzed using a polymerase chain reaction based restriction fragment length polymorphism assay. Conditional multiple logistic regression analysis was used to calculate adjusted odds ratios and 95% confidence intervals after adjusting for confounding factors. Results: The combined Gln/Gln genotype of XRCC1 and XPD genes (OR=2.78, CI=1.05-7.38; p=0.040) was significantly associated with increased risk for lung cancer. Interaction of XRCC1Gln/Gln genotype with exposure of wood combustion (OR=2.56, CI=1.16-5.66; p=0.020), exposure of cooking oil fumes (OR=3.45, CI=1.39-8.58; p=0.008) and tobacco smoking (OR=2.54, CI=1.21-5.32; p=0.014) and interaction of XPD with betel quid chewing (OR=2.31, CI=1.23-4.32; p=0.009) and tobacco smoking (OR=2.13, CI=1.12-4.05; p=0.022) were found to be significantly associated with increased risk for lung cancer. Conclusions: Gln/Gln alleles of both XRCC1 and XPD genes appear to amplify the effects of household exposure, smoking and betel quid chewing on lung cancer risk in the study population.

#XRCC1 #XPD #environmental factors #interaction #lung cancer #high risk population #North-East India

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