Lack of any Impact of Histopathology Type on Prognosis in Patients with Early-Stage Adenocarcinoma and Squamous Cell Carcinoma of the Uterine Cervix

Teke, Fatma; Yoney, Adnan; Teke, Memik; Inal, Ali; Urakci, Zuhat; Eren, Bekir; Zincircioglu, Seyit Burhanedtin; Buyukpolat, Muhammed Yakup; Ozer, Ali; Isikdogan, Abdurrahman; Unsal, Mustafa

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자료유형: 학술저널

저자정보: Teke, Fatma (Department of Radiation Oncology, Faculty of Medicine, Dicle University) Yoney, Adnan (Department of Radiation Oncology, Faculty of Medicine, Karadeniz Technical University) Teke, Memik (Department of Radiology, Faculty of Medicine, Dicle University) Inal, Ali (Department of Medical Oncology, Faculty of Medicine, Dicle University) Urakci, Zuhat (Department of Medical Oncology, Faculty of Medicine, Dicle University) Eren, Bekir (Okmeydani Training and Research Hospital) Zincircioglu, Seyit Burhanedtin (Department of Radiation Oncology, Faculty of Medicine, Dicle University) Buyukpolat, Muhammed Yakup (Okmeydani Training and Research Hospital) Ozer, Ali (Department of Obstetrics and Gynecology, Faculty of Medicine, Dicle University) Isikdogan, Abdurrahman (Department of Medical Oncology, Faculty of Medicine, Dicle University) Unsal, Mustafa (Okmeydani Training and Research Hospital)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제15권 제6호

발행연도: 2014.1

수록면: 2,815 - 2,819 (5page)

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Background: The aim of this study was to evaluate the prognosis of patients with stage IA-IIB cervical carcinoma and to investigate a possible correlation of histology with prognosis. Materials and Methods: Two hundred fifty one patients with adenocarcinoma and squamous cell carcinoma (SCC) histology for FIGO (International Federation of Gynecology and Obstetrics) stage IA-IIB uterine cervical carcinomas at the Radiation Oncology Clinic of GH Okmeydan Training and Research Hospital between January 1996 and December 2006 were selected, analyzed retrospectively and evaluated in terms of general characteristics and survival. Disease-free survival (DFS) and overall survival (OS) was calculated using the Kaplan-Meier method and differences were compared with the log-rank test. Multivariate analysis using a Cox-proportional hazards model was used to adjust for prognostic factors and to estimate hazard ratio (HR) with 95% confidence interval (CI). Results: There was no differences between the two tumour types in age, stage, pelvic nodal metastasis, parametrial invasion, surgical margin status, DSI, LVSI, maximal tumor diameter, grade, and treatment modalities. 5-year OS and DFS were 73% and 77%, versus 64% and 69%, for SCC and adenocarcinoma, respectively (p> 0.05). Multivariate analysis revealed independent prognostic factors including pelvic nodal metastasis and resection margin status for OS (p=0.008, p=0.002, respectively). Conclusions: Prognosis of FIGO stage IA-IIB cervical cancer patients was found to be the same for those with adenocarcinoma and SCC.

#Adenocarcinoma #squamous cell carcinoma #uterine cervical carcinoma #histology #prognosis

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