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학술저널
저자정보
Gao, Mei-Li (Institute of Mitochondrial Biology and Medicine, Department of Biological Science and Engineering, The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School) Chen, Lei (Institute of Mitochondrial Biology and Medicine, Department of Biological Science and Engineering, The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School o) Li, Yong-Fei (School of Materials and Chemical Engineering, Xi'an Technological University) Xue, Xiao-Chang (State Key Laboratory of Cancer Biology, Department of Biopharmaceutics School of Pharmacy, Fourth Military Medical University) Chen, Lan (Center of Shared Experimental Facilities, The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University) Wang, Li-Na (Neurology Department, Ninth Affiliated Hospital of Medical College of Xi'an Jiaotong University) Shah, Walayat (Insti) Kong, Yu
저널정보
아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제15권 제17호
발행연도
2014.1
수록면
7,105 - 7,112 (8page)

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In this study, we investigated oxidative stress and tumor marker levels of polycyclic aromatic hydrocarbons (PAHs) in 136 coke oven workers and in 60 control subjects, and evaluated the correlation between oxidative stress and tumor marker levels. Questionnaires on basic demographic information were also administered. Significant differences in employment time and percentages of alcohol drinkers were observed between the control and exposed groups. PAH exposure was assessed using urinary 1-hydroxy-pyrene (1-OHP) levels and was found to be significantly higher in workers than in the controls. Significant differences (P<0.001) of MDA, GST, LDH, NSE, Cyfra21-1, and of SCC and TNF-a (P<0.0001 and P<0.05, P<0.001, respectively) levels were observed among controls and coke-oven workers, except for bottom coke oven workers. Associations between age and risk of increased TNF-a, smoking and increased GST activities, and drinking with increased MDA concentrations, were marginal (P=0.055, P=0.048, P=0.057, respectively). The association between smoking with MDA (P=0.004), NSE (P=0.005), SCC (P=0.004) andTNF-a (P<0.001), and drinking with TNF-a levels was significant (P=0.012). In addition, a significant positive correlation between oxidative stress and tumor markers was found in the present study. These results suggest that a synergistic increase of oxidative stress and tumor markers induced by PAHs may play a role in toxic responses for PAHs in coke oven workers.

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