Prognostic Role of Circulating Tumor Cells in Patients with Pancreatic Cancer: a Meta-analysis

Ma, Xue-Lei; Li, Yan-Yan; Zhang, Jing; Huang, Jing-Wen; Jia, Hong-Yuan; Liu, Lei; Li, Ping

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자료유형: 학술저널

저자정보: Ma, Xue-Lei (Cancer Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University) Li, Yan-Yan (Cancer Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University) Zhang, Jing (Cancer Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University) Huang, Jing-Wen (Cancer Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University) Jia, Hong-Yuan (Cancer Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University) Liu, Lei (Cancer Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University) Li, Ping (Cancer Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제15권 제15호

발행연도: 2014.1

수록면: 6,015 - 6,020 (6page)

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Background: Isolation and characterization of circulating tumor cells (CTCs) in patients suffering from a variety of different cancers have become hot biomarker topics. In this study, we evaluated the prognostic value of CTCs in pancreatic cancer. Materials and Methods: Initial literature was identified using Medline and EMBASE. The primary data were hazard ratios (HRs) with 95% confidence intervals (CIs) of survival outcomes, including overall survival (OS) and progression free survival/recurrence free survival (PFS/RFS). Results: A total of 9 eligible studies were included in this meta-analysis, published between 2002 and 2013. The estimated pooled HR and 95%CI for OS for all studies was 1.64 (95%CI 1.39-1.94, p<0.00001) and the pooled HR and 95%CI for RFS/DFS was 2.36 (95%CI 1.41-3.96, p<0.00001). The HRs and 95%CIs for OS and RFS/DFS in patients before treatment were 1.93 (95%CI 1.26-2.96, p=0.003) and 1.82 (95%CI 1.22-2.72, p=0.003), respectively. In patients receiving treatment, the HRs and 95%CI for OS and RFS/DFS were 1.37 (95%CI 1.00-1.86, p=0.05) and 1.89 (95%CI 1.01-3.51, p=0.05), respectively. Moreover, the pooled HR and 95%CI for OS in the post-treatment group was 2.20 (95%CI 0.80-6.02, p=0.13) and the pooled HR for RFS/DFS was 8.36 (95%CI 3.22-21.67, p<0.0001). Conclusions: The meta-analysis provided strong evidence supporting the proposition that CTCs detected in peripheral blood have a fine predictive role in pancreatic patients especially on the time point of post-treatment.

#CTCs #pancreatic #prognosis #meta-analysis

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Ma, Xue-Lei

소속기관 Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, West China Medical School