Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration in the Diagnosis of Lymphoma

Senturk, Aysegul; Babaoglu, Elif; Kilic, Hatice; Hezer, Habibe; Dogan, Hayriye Tatli; Hasanoglu, Hatice Canan; Bilaceroglu, Semra

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자료유형: 학술저널

저자정보: Senturk, Aysegul (Department of Pulmonary Diseases, Ataturk Training and Research Hospital) Babaoglu, Elif (Department of Pulmonary Diseases, Ataturk Training and Research Hospital) Kilic, Hatice (Department of Pulmonary Diseases, Ataturk Training and Research Hospital) Hezer, Habibe (Department of Pulmonary Diseases, Ataturk Training and Research Hospital) Dogan, Hayriye Tatli (Department of Pathology, Ataturk Training and Research Hospital) Hasanoglu, Hatice Canan (Department of Pulmonary Diseases, Yildirim Beyazid University School of Medicine) Bilaceroglu, Semra (Department of Pulmonary Medicine, Izmir Training and Research Hospital for Thoracic Medicine and Surgery)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제15권 제10호

발행연도: 2014.1

수록면: 4,169 - 4,173 (5page)

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Background: Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is highly accurate in diagnosing mediastinal lymphadenopathies of lung cancer and benign disorders. However, the utility of EBUS-TBNA in the diagnosis of mediastinal lymphomas is unclear. The aim of this study was to determine the diagnostic value of EBUS-TBNA in patients with suspected lymphoma. Materials and Methods: Sixty-eight patients with isolated mediastinal lymphadenopathy and suspected of lymphoma were included in the study. EBUS-TBNA was performed on outpatients under moderate sedation. The sensitivity, specificity, negative predictive value and diagnostic accuracy of EBUS-TBNA were calculated. Results: Sixty-four patients were diagnosed by EBUS-TBNA, but four patients with non-diagnostic EBUS-TBNA required surgical procedures. Thirty-five (51.5%) patients had sarcoidosis, six (8.8%) had reactive lymphadenopathy, nine (13.3%) had tuberculosis, one (1.5%) had squamous cell carcinoma, two (2.9%) had sarcoma and fifteen (22%) had lymphoma (follicular center cell, large B-cell primary, and Hodgkin lymphomas in three, two, and ten, respectively). Of the 15 lymphoma patients, thirteen were diagnosed by EBUS and two by thoracotomy and mediastinoscopy. The sensitivity, specificity, negative predictive value, and diagnostic accuracy of EBUS-TBNA for the diagnosis of lymphoma were calculated as 86.7%, 100%, 96.4%, and 97%, respectively. Conclusions: EBUS-TBNA can be employed in the diagnosis of mediastinal lymphoma, instead of more invasive surgical procedures.

#EBUS-TBNA #lymphoma #mediastinal lymphadenopathy

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