Relation of Alcohol/Tobacco use with Metastasis, Hormonal (Estrogen and Progesterone) Receptor Status and c-erbB2 Protein in Mammary Ductal Carcinoma

Leon-Hernandez, Saul Renan; Padilla, Eleazar Lara; Algara, Alfredo Cortes; Rodriguez, Noemi Cardenas; Sanchez, Esau Floriano; Cruz, Jaime Lopez; Barradas, Cesar Miguel Mejia; Bandala, Cindy

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저자정보: Leon-Hernandez, Saul Renan (Instituto Nacional de Rehabilitacion, Departamento de Apoyo a la Investigacion) Padilla, Eleazar Lara (Instituto Politecnico Nacional, Escuela Superior de Medicina, Seccion de Estudios de Posgrado e Investigacion) Algara, Alfredo Cortes (Instituto Politecnico Nacional, Escuela Superior de Medicina, Seccion de Estudios de Posgrado e Investigacion) Rodriguez, Noemi Cardenas (Instituto Politecnico Nacional, Escuela Superior de Medicina, Seccion de Estudios de Posgrado e Investigacion) Sanchez, Esau Floriano (Secretaria de la Defensa Nacional, Universidad del Ejercito y Fuerza Aerea Mexicanos, Subdireccion de Investigacion. Escuela Militar de Graduados de Sanidad, Laboratorio de Inve) Cruz, Jaime Lopez (Secretaria de la Defensa Nacional, Hospital Militar de Especialidades de la Mujer y Neonatologia) Barradas, Cesar Miguel Mejia (Instituto Politecnico Nacional, Escuela Superior de Medicina, Seccion de Estudios de Posgrado e Investigacion) Bandala, Cindy (Instituto Nacional de Rehabilitacion, Departamento de Apoyo a la Investigacion)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제15권 제14호

발행연도: 2014.1

수록면: 5,709 - 5,714 (6page)

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Background: An association between alcohol/tobacco use and risk of metastasis in breast cancer has been clearly shown. Materials and Methods: The present study explored, in 48 samples of tissue from mammary ductal carcinoma (taken from Mexican women with an average age of $58.2{\pm}10.9$ years), the association of risk of metastasis with the status of hormonal receptors and the c-erbB2 protein (by immunohistochemistry) as well as clinical, histopathological and sociodemographic factors. Results: Of 48 patients, 41.6% (20/48) presented with metastasis, 43.8% were positive for the estrogen receptor (RE+), 31.3% for the progesterone receptor (RP+) and 47.7% for c-erbB2 (c-erbB2+). The following combinations were found: RE+/RP+/c-erbB2+ 8.3%, RE+/RP+ 22.9%, RE+/RP- 20.8%, RE-/RP+ 8.3%, RE-/RP-/c-erbB2- 22.9% and RE-/RP- 47.8%. There were 12 patients who used alcohol/tobacco, of which 91.6% did not present metastasis and 81.9% were RE-/RP-. Compared to the RE-/RP-/c-erbB2+, the RE+/RP+/c-erbB2+ group had a 15-fold greater risk for metastasis (95%CI, 0.9-228.8, p=0.05). The carriers of the double negative hormonal receptors had a 4.7 fold greater probability of being (or having been) smokers or drinkers (95%CI, 1.0-20.4, p = 0.03). Conclusions: There was a clear protective effect of using alcohol and/or tobacco, in the cases included in the present study of mammary ductal carcinoma, associated with double negative hormonal receptors. However, this association could be due to a protective factor not measured (Neyman bias) or to a bias inherent in the rate of hospitalization (Berkson fallacy). This question should be explored in a broad prospective longitudinal study.

#Breast cancer #alcoholism #tobacco use #hormonal receptors #metastasis #Her/neu

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